ChemicalBook >제품 카탈로그 >생화학 공학>억제제>아폽토시스>P53 활성제>TENOVIN-1

TENOVIN-1

TENOVIN-1 구조식 이미지

카스 번호:: 380315-80-0

상품명:: TENOVIN-1

동의어(영문):: CS-571;TENOVIN-1;Tenovin-1, >=98%;TENOVIN-1 USP/EP/BP;TENOVIN-1;TENOVIN 1;N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin 1;Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide

CBNumber:: CB92446962

분자식:: C20H23N3O2S

포뮬러 무게:: 369.48

MOL 파일:: 380315-80-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 113

TENOVIN-1 속성

녹는점: >180°C (Subl.)

밀도: 1.238±0.06 g/cm3(Predicted)

저장 조건: Sealed in dry,Room Temperature

용해도: DMSO에 용해됨(가온 시 10mg/ml)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 9.09±0.70(Predicted)

색상: 하얀색

안정성: 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.

안전

유엔번호(UN No.)	3077
HS 번호	29242990

TENOVIN-1 C화학적 특성, 용도, 생산

개요

Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 μM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD⁺-dependent class III histone deacetylases that belong to the sirtuin family. While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.

용도

Tenovin 1 is a sirtuin inhibitor.

생물학적 활성

p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21 CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro .

TENOVIN-1 준비 용품 및 원자재

원자재

준비 용품

TENOVIN-1 공급 업체

글로벌( 113)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29897	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	25553	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58

TENOVIN-1 관련 검색:

Tenovin-2 Y16 LY 303511 (hydrochloride) PFK-015 CCT 137690 CTS-1027 TG101209 BIX 02189 BMS 833923 MS436 CNX-1351 Mutant IDH1 inhibitor Pifithrin-α (PFTα) N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine NSC 207895 Alpelisib (BYL719) Nutlin-3 Tenovin-6