(R)-(+)-1-(4-메틸페닐)에틸아민
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(R)-(+)-1-(4-메틸페닐)에틸아민 속성
- 녹는점
- <-20°C
- 끓는 점
- 205 °C (lit.)
- 알파
- 37 º (NEAT)
- 밀도
- 0.919 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.521(lit.)
- 인화점
- 180 °F
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- 산도 계수 (pKa)
- 9.20±0.10(Predicted)
- Specific Gravity
- 0.919
- optical activity
- [α]20/D +37°, neat
- 감도
- Air Sensitive
- BRN
- 3195425
- CAS 데이터베이스
- 4187-38-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22-34 | ||
| 안전지침서 | 16-26-27-36/37/39-45 | ||
| 유엔번호(UN No.) | UN 2619 8/PG 2 | ||
| WGK 독일 | 3 | ||
| 위험 등급 | 8 | ||
| 포장분류 | III | ||
| HS 번호 | 2921490090 |
(R)-(+)-1-(4-메틸페닐)에틸아민 C화학적 특성, 용도, 생산
화학적 성질
Colorless to light yellow liquid용도
(R)-(+)-α,4-Dimethylbenzylamine can be used as a chiral salt of keto acid, employed in the solid-state photolysis studies of α-mesitylacetophenone derivatives.주요 응용
(R)-(+)-α,4-Dimethylbenzylamine reacts with 1,5-difluoro-2,4-dinitrobenzene (DFDNB) to form a chiral derivative reagent(CDR) via substitution of one fluorine atom.일반 설명
(R)-(+)-α,4-Dimethylbenzylamine is a chiral amine.Synthesis
(R)-(+)-1-(4-methylphenyl)ethylamine was synthesized via a series of chemical reactions with (R)-N-[1-(4-methylphenyl)ethyl]acetamide. The steps are as follows:1 g of the compound obtained in the previous stage will be used. 2 g of n-butanol was added, 0.63 g of potassium hydroxide was added, and the temperature was raised to 100 ° C. After 24 hours of heat preservation, cool down to 10 to 20 ℃. After adding water and stirring for 0.5 hours, the mixture was allowed to stand for separation, and the organic layer was concentrated to n-butanol, and then subjected to vacuum distillation (80-100 ℃ packed column) to obtain (R)-1-(4-methylphenyl)ethylamine 0.63 g. The yield was 82%, the HPLC purity was 96.3%, and the enantiomer was 0.8%.
structure and hydrogen bonding
(R)-(+)-1-(4-Methylphenyl)ethylamine is a chiral molecule studied in the context of crystallographic analysis and optimization. Through X-ray diffraction analysis, the crystal structure of (R)-(+)-1-(4-Methylphenyl)ethylamine was determined, revealing the presence of a significant hydrogen bond between the amine group and one of the carbonyl groups. This hydrogen bond plays a crucial role in stabilizing the (R)-(+)-1-(4-Methylphenyl)ethylamine molecule, which is a recurring pattern observed in structurally similar compounds. Furthermore, the (S)-(+)-enantiomer of (R)-(+)-1-(4-Methylphenyl)ethylamine was synthesized using an enantiopure precursor, establishing an efficient method to obtain this desired form of the molecule.(R)-(+)-1-(4-메틸페닐)에틸아민 준비 용품 및 원자재
원자재
준비 용품
(R)-(+)-1-(4-메틸페닐)에틸아민 공급 업체
글로벌( 150)공급 업체
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| Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 |
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sales@tnjchem.com | China | 34563 | 58 |
| Jinjiangchem Corporation | 512-50133713 |
sales@jinjiangchem.com | CHINA | 1072 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49734 | 58 |