CARBENICILLIN INDANYL SODIUM

CARBENICILLIN INDANYL SODIUM C화학적 특성, 용도, 생산

개요

Carbenicillin indanyl was synthesized by Pfizer in 1972 as an orally active carbenicillin. It shows strong activity against a variety of bacteria in vitro, and, when administered orally, it behaves as carbenicillin after being hydrolyzed by intestinal esterase.

용도

Carbenicillin indanyl sodium has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.

Clinical Use

Efforts to obtain orally active forms of carbenicillin led to theeventual release of the 5-indanyl ester carbenicillin indanyl,6-[2-phenyl-2-(5-indanyloxycarbonyl)acetamido]penicillanicacid (Geocillin), in 1972. Approximately 40% of theusual oral dose of indanyl carbenicillin is absorbed. After absorption,the ester is hydrolyzed rapidly by plasma and tissueesterases to yield carbenicillin. Thus, although the highlylipophilic and highly protein-bound ester has in vitro activitycomparable with that of carbenicillin, its activity in vivo isdue to carbenicillin. Indanyl carbenicillin thus provides anorally active alternative for the treatment of carbenicillinsensitivesystemic and urinary tract infections caused byPseudomonas spp., indole-positive Proteus spp., and selectedspecies of Gram-negative bacilli.
Clinical trials with indanyl carbenicillin revealed a relativelyhigh frequency of GI symptoms (nausea, occasionalvomiting, and diarrhea). It seems doubtful that the highdoses required for the treatment of serious systemic infectionscould be tolerated by most patients. Indanyl carbenicillinoccurs as the sodium salt, an off-white, bitter powderthat is freely soluble in water. It is stable in acid. It should beprotected from moisture to prevent hydrolysis of the ester.

CARBENICILLIN INDANYL SODIUM 준비 용품 및 원자재

원자재

준비 용품

CARBENICILLIN INDANYL SODIUM 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	8853	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	info@afinechem.com	China	15395	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9823	79
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973186 4009686088	3193328036@qq.com	China	18352	68
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226	sales@rrkchem.com	China	56077	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
guoyungurui	18162595016	3287908757@qq.com	China	10337	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

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