CARBENICILLIN INDANYL SODIUM
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CARBENICILLIN INDANYL SODIUM 속성
- 녹는점
- 207-213°
- 저장 조건
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- 용해도
- DMSO(약간 용해됨), 물(약간 용해됨, 가열, 초음파 처리)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성, 온도에 민감함
안전
HS 번호 | 2941106000 |
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CARBENICILLIN INDANYL SODIUM C화학적 특성, 용도, 생산
개요
Carbenicillin indanyl was synthesized by Pfizer in 1972 as an orally active carbenicillin. It shows strong activity against a variety of bacteria in vitro, and, when administered orally, it behaves as carbenicillin after being hydrolyzed by intestinal esterase.용도
Carbenicillin indanyl sodium has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.Clinical Use
Efforts to obtain orally active forms of carbenicillin led to theeventual release of the 5-indanyl ester carbenicillin indanyl,6-[2-phenyl-2-(5-indanyloxycarbonyl)acetamido]penicillanicacid (Geocillin), in 1972. Approximately 40% of theusual oral dose of indanyl carbenicillin is absorbed. After absorption,the ester is hydrolyzed rapidly by plasma and tissueesterases to yield carbenicillin. Thus, although the highlylipophilic and highly protein-bound ester has in vitro activitycomparable with that of carbenicillin, its activity in vivo isdue to carbenicillin. Indanyl carbenicillin thus provides anorally active alternative for the treatment of carbenicillinsensitivesystemic and urinary tract infections caused byPseudomonas spp., indole-positive Proteus spp., and selectedspecies of Gram-negative bacilli.Clinical trials with indanyl carbenicillin revealed a relativelyhigh frequency of GI symptoms (nausea, occasionalvomiting, and diarrhea). It seems doubtful that the highdoses required for the treatment of serious systemic infectionscould be tolerated by most patients. Indanyl carbenicillinoccurs as the sodium salt, an off-white, bitter powderthat is freely soluble in water. It is stable in acid. It should beprotected from moisture to prevent hydrolysis of the ester.
CARBENICILLIN INDANYL SODIUM 준비 용품 및 원자재
원자재
준비 용품
CARBENICILLIN INDANYL SODIUM 공급 업체
글로벌( 19)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 8853 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15395 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 |
sj_scrc@sinopharm.com | China | 9823 | 79 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973186 4009686088 |
3193328036@qq.com | China | 18352 | 68 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 |
sales@rrkchem.com | China | 56077 | 58 |
Energy Chemical | 021-58432009 400-005-6266 |
marketing1@energy-chemical.com | China | 44843 | 58 |
guoyungurui | 18162595016 |
3287908757@qq.com | China | 10337 | 58 |
TargetMol Chemicals Inc. | 15002134094 |
marketing@targetmol.cn | China | 28091 | 58 |
CARBENICILLIN INDANYL SODIUM 관련 검색:
페니실린 감마-일라디산염 세포
Ticarcillin
5-INDANOL
CARINDACILLIN
CARBENICILLIN PHENYL SODIUM
M-CRESYL PHENYLACETATE
CARBENICILLIN INDANYL SODIUM
sodium [2S-(2alpha,5alpha,6beta)]-6-[(1,3-dioxo-3-phenoxy-2-phenylpropyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
CARBENICILLIN
AKOS BC-1945