1,3,4-Thiadiazole
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1,3,4-Thiadiazole 속성
- 녹는점
- 42.5°C
- 끓는 점
- 204°C
- 밀도
- 1.299 (estimate)
- 굴절률
- 1.5300 (estimate)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- -0.33±0.10(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Warning | |||||||||||||||||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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1,3,4-Thiadiazole C화학적 특성, 용도, 생산
개요
1,3,4-Thiadiazole is a five-membered, aromatic, weakly basic, planer, electron-deficient, conjugated heterocyclic ring system comprised of two carbon atoms, one sulfur atom, and two pyridine-like nitrogen atoms present at the 3- and 4-positions of the ring. The dipole moment (3.25 D) for 1,3,4-thiadiazole suggests that it is a polar symmetric molecule with pseudo-aromatic character. The carbon atoms at the 2- and 5-positions are electron deficient because of the inductive effect of nitrogen and sulfur and thus they are inert toward electrophilic substitution but reactive toward nucleophilic attack.용도
1,3,4-Thiadiazole, a bioisostere of the thiazole ring, has been used in the synthesis of cephalosporine and cefazedone, which are used as antibiotics. Megazole is another 1,3,4-thiadiazole-based drug, widely used in the treatment of African trypanosomes, also known as sleeping sickness. Azetepa, a phosphoruscontaining drug, has been used for the treatment of cancer. Tebtheuron is known as a broad-spectrum herbicide and is used to control a variety of weeds and herbaceous and woody plants. Numerous thiadiazole derivatives are patented as bactericides, insecticides, and fungicides.화학 반응
Atomic charges have been calculated by the DFT method. The maximum charge was found at the S atom (0.818) and thus it is the favorite position for soft nucleophilic attack. The atomic charge on each carbon is ?0.3275. Because of the presence of the two pyridine-like nitrogen atoms in the ring, which make the C2 - and C5 -positions electronically poor, nucleophilic substitution of the leaving groups present at either the C2 - or C5 -position becomes highly facile. However, the atomic charge on N3 and N4 (?0.0308) makes them preferential sites for electrophilic attack and readily N-alkylated or N-acylated. In strongly basic conditions the thiadiazole ring leads to ring fission.1,3,4-Thiadiazole 준비 용품 및 원자재
원자재
준비 용품
1,3,4-Thiadiazole 공급 업체
글로벌( 13)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 |
cb6@aikonchem.com | China | 16687 | 50 |
ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 |
sales@atkchemical.com | China | 9994 | 55 |
Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 |
kungfu1217@163.com | China | 9171 | 58 |
JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 |
jinoupharma@163.com | China | 11732 | 58 |
Bide Pharmatech Ltd. | 400-1647117 13681763483 |
product02@bidepharm.com | China | 62163 | 58 |
Guangzhou Austine Biotechnology Co., LTD | 17727342298 |
2781109436@qq.com | China | 2004 | 58 |
Henan Vcommend Consultrading Co., Ltd. | 13393721940 |
sales@vcommend.com | China | 9911 | 58 |
Guangdong Shengke Biochemical Technology Co., Ltd. | 189-25112307 18925113981 |
3809205144@qq.com | China | 10000 | 58 |
Guangdong Wengjiang Chemical Reagent Co.,Ltd. | 0751-2815983 13927872582 |
3008325437@qq.com | China | 2873 | 58 |
1,3,4-Thiadiazole 관련 검색:
2,5-디메르캅토-1,3,4-티아디아졸 2,5-디머켑토-1,3,4-티아디아졸 이칼륨 염 5-메틸-1,3,4-티아디아졸-2-티올 5-아미노-1,3,4-티아디아졸-2-티올
2-Amino-5-ethyl-1,3,4-thiadiazole
2-AMINO-5-ETHYLTHIO-1,3,4-THIADIAZOLE
2,5-DIMETHYL-1,3,4-THIADIAZOLE
2-Amino-5-methyl-1,3,4-thiadiazole
Acetazolamide
2-(METHYLAMINO)-5-(TRIFLUOROMETHYL)-1,3,4-THIADIAZOLE
2-bromo-5-(trifluoromethyl)-1,3,4-thiadiazole
2,5-BIS(4-PYRIDYL)-1,3,4-THIADIAZOLE
2,5-DIAMINO-1,3,4-THIADIAZOLE
2-AMINO-5-TERT-BUTYL-1,3,4-THIADIAZOLE
2-Mercapto-1,3,4-thiadiazol
2-Amino-1,3,4-thiadiazole
5-AMINO-2-DIISOPROPYLAMINO-1,3,4-THIADIAZOLE
2-AMINO-5-TRIFLUOROMETHYL-1,3,4-THIADIAZOLE