아미카르발리드

아미카르발리드 C화학적 특성, 용도, 생산

Originator

Diampron,May and Baker

Manufacturing Process

m-Aminobenzonitrile (50 g) in anhydrous pyridine (200 ml) was treated with a solution of phosgene (15 ml) in anhydrous toluene (100 ml) over 10 min with mechanical stirring. The red solution was heated for 0.5 hour on the steam bath, cooled, and added to water (2 litres). The pale grey precipitate was filtered off, washed with ether, and crystallised from methanol (250 ml). N,N1- Di(m-cyanophenyl)urea separated as grey prisms, melting point 205-206°C.
A suspension of N,N1-di(m-cyanophenyl)urea (42 g) in anhydrous chloroform (420 ml), containing anhydrous ethanol (70 ml), was saturated with anhydrous hydrogen chloride at 0-5°C. After setting aside for 2 hours, a clear solution was obtained, which began to crystallise. After a week, the crystals were filtered off, washed well with anhydrous ether, and dried over calcium chloride. The iminoether hydrochloride so obtained (72 g) was added to saturated anhydrous ethanolic ammonia (720 ml), and the suspension heated at 55-60°C for 6 hours. After cooling to 20°C the crystals were filtered off, and recrystallized from 2 N hydrochloric add (300 ml). 3,31- Diamidinodiphenylurea dihydrochloride monohydrate separated as white prisms, melting point 286°C (decomp.).
In practice it is usually used as isethonate salt.

Therapeutic Function

Antiprotozoal

아미카르발리드 준비 용품 및 원자재

원자재

준비 용품

아미카르발리드 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	281	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19884	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	+8618950047208	ellena@amitychem.com	China	43395	58
Chemwill Asia Co.,Ltd.	86-21-51086038	chemwill_asia@126.com	CHINA	23912	58
Chengdu HuaXia Chemical Reagent Co. Ltd	400-1166-196 13458535857	cdhxsj@163.com	China	13350	58

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