ChemicalBook

16561-29-8(PHORBOL 12-MYRISTATE 13-ACETATE) Product Description

PHORBOL 12-MYRISTATE 13-ACETATE Structure16561-29-8
CAS No.16561-29-8
Chemical Name:PHORBOL 12-MYRISTATE 13-ACETATE
CBNumber:CB2376433
Molecular Formula:C36H56O8
Formula Weight:616.83
MOL File:Mol file
PHORBOL 12-MYRISTATE 13-ACETATE Synonyms:
13-o-acetylphorbol12-myristate
4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
(1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
12-TETRADECANOYL PHORBOL 13-ACETATE

PHORBOL 12-MYRISTATE 13-ACETATE Property

Melting point: 65-79oC
Boiling point: 571.87°C (rough estimate)
Density  1.17±0.1 g/cm3 (20 ºC 760 Torr)
refractive index  1.4900 (estimate)
storage temp.  -20°C
solubility  DMSO: DMSO solutions can be stored dark at −20°C for at least six months.soluble
pka 11.19±0.70(Predicted)
form  Fine Crystalline Powder
color  Off-white to light yellow
Water Solubility  Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Sensitive  Light Sensitive
BRN  2407201
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey PHEDXBVPIONUQT-RGYGYFBISA-N
CAS DataBase Reference 16561-29-8(CAS DataBase Reference)
EPA Substance Registry System 12-O-Tetradecanoylphorbol 13-acetate (16561-29-8)

Safety

Hazard Codes : Xi
Risk Statements : 38-36/37/38
Safety Statements : 36/37-26
RIDADR : 2928
WGK Germany : 3
RTECS : QH4377000
F : 8-10
HazardClass : 6.1(a)
PackingGroup : II
HS Code : 29153900
Hazardous Substances Data: 16561-29-8(Hazardous Substances Data)
Toxicity: Diesters of phorbol, particularly 12-O-tetradecanoylphorbol 13-acetate, also known as phorbol myristate acetate, have been identified as the potent, highly lipophilic tumor-promoting components in croton oil. They are potent promoters of skin tumors in vivo and have been shown to transform cultured fibroblasts and embryonic cells previously exposed to polycyclic aromatic hydrocarbon carcinogens in vitro. The structure of phorbol, the parent alcohol is shown below. Phorbol esters also have important effects on leukocytes and on the immune system of the intact animal. There appears to be a specific receptor for phorbol esters on T cells, a finding that may account for the selective toxicity of phorbol esters for T cells. The mechanism of tumor promotion by phorbol esters is still largely unknown, but findings suggest an initial cell membrane interaction (often with stimulation of second messenger synthesis and increased protein kinase activity), with subsequent effects on nuclear regulatory events.

PHORBOL 12-MYRISTATE 13-ACETATE Suppliers

Global( 242)Suppliers     
SupplierTelEmailCountryProdListAdvantage
Nanjing Spring & Autumn Biological Engineering Co., Ltd. 025-84430028sale02@cqherb.comChina 280 59
Shanghai Hanguang Biotechnology Co., LTD  3007522984@qq.comChina 199 58
Chengdu Biopurify Phytochemicals Ltd.  sales@biopurify.comChina 3777 58
Shanghai Standard Technology Co.,Ltd. 021-021-57127007-6622-6622zhaok@nature-standard.comChina 3016 58
PureChemland Co.,Ltd.  3848291069@qq.comChina 3536 58
Guangzhou Younan Technology Co., Ltd 020-020-82000279sales@ubiochem.comChina 4324 58
ShangHai Angti Biotechnology Co., Ltd.  info@angtibio.comChina 4922 55
Watson Biotechnology Co.,Ltd +86-18186686046sales01@watsonbiotech.cnChina 5864 58
16561-29-8(PHORBOL 12-MYRISTATE 13-ACETATE) Related Search:
13-o-acetylphorbol12-myristate 4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa( 5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b, 4BETA-PHORBOL 12-MYRISTATE 13-ACETATE 4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE 4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE (1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE 12-TETRADECANOYL PHORBOL 13-ACETATE PHORBOL 12-MYRISTATE 13-ACETATE, SYNTHET IC PHORBOL 12-MYRISTATE 13-ACETATE,*MOLECUL AR BIOLOGY PHORBOL 12-MYRISTATE 13-ACETATE FROM & Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa3,4benz1,2-eazulen-9-yl ester 4B-PHORBOL-12-MYRISTATE-13-ACETATE 2-ORTHO-TETRADECANOYL-PHORBOL-13-ACETATE O-TETRADECANOYLPHORBOL-13-ACETATE 12-ORTHO-TETRADECANOYLPHORBOL-13-ACETATE 12-O-Tetradecanoylphorbol 13-acetate, PMA, TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate Phorbol 12-myristate 13-acetate,99% Phorbol 12-myristate 13-acetate,97% PHORBOL(12-MYRISTOYL-13-ACETYL) ANALYTICAL GRADE Phorbol 12-myristate 13-acetate,12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA Phorbol 12-Myristate 13-Acetate >99.5% Phorbol-12-Myristate-13-acetate / 12-Tetradecanoyl phorbol-13-acetate, TPA PMA, TPA, Cocarcinogen A1 12-O-TETRADECANOYL PHORBOL-13-ACETATE;COCARCINOGEN A1; COCARCINOGEN C3 Cocarcinogen A1 Cocarcinogen C3 (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate 12-O-tetradecanoyl phorbol-13-acetate(CAS：16561-29-8) 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate PHORBOL 12-MYRISTATE 13-ACETATE, SYN (1AR,1bS,4aR,7aS,7bS,8R,9R,9aS) -1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate -9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl) InSolution? Phorbol-12-myristate-13-acetate PHORBOL 12-MYRISTATE 13-ACETATE PHORBOL (12-MYRISTOYL-13-ACETYL) 8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram a-tetramethyl-5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,9a-acetate -e)azulen-9-ylester,(1ar-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta factora1 factora1(crotonoil) factora1[crotonoil] hydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1h-cyclopropa(3,4)benz(1,2 myristicacid,9-esterwith1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-decahydr myristicacid,9-esterwith1,1aalpha,1bbeta,4,4a,7aalpha,7b,8,9,9a-decahydro-4 o-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-alph pentahydroxy-tigliadienone-monoacetate(c)monomyristate(b) phorbol12-tetradecanoate13-acetate phorbolacetate,myristate phorbolmonoacetatemonomyristate phorbolmyristateacetate pma(tumorpromoter) tetradecanoicacid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-di tetradecanoylphorbolacetate ,9aalpha))- 1,6,8-beta-tetramethyl-l)-9a-acetate9-myristate
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