4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE manufacturers and suppliers

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE suppliers

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE

CAS:: 101574-65-6

MF:: C17H18N2O2

MW:: 282.34

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Properties

Density: 1.12

storage temp.: Inert atmosphere,2-8°C

solubility: DMSO: >10mg/mL

form: powder

pka: 8.48±0.15(Predicted)

color: white to off-white

Safety Information

Symbol(GHS): GHS07,GHS09

Signal word: Warning

Hazard statements: H317-H410

Precautionary statements: P261-P272-P273-P280-P302+P352-P333+P313

Hazard Codes: Xi,N

Risk Statements: 43-50/53

Safety Statements: 36/37-60-61

RIDADR: UN 3077 9 / PGIII

WGK Germany: 3

HazardClass: 9

Use

The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]

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