17-AAG suppliers
17-AAG
- CAS:
- 75747-14-7
- MF:
- C31H43N3O8
- MW:
- 585.69
Suppliers by country/region
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Properties
- Melting point:
- 201-203°C
- Boiling point:
- 797.8±60.0 °C(Predicted)
- Density
- 1.21
- RTECS
- LX8932000
- Flash point:
- >110°(230°F)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 8.62±0.70(Predicted)
- color
- Purple or dark red
- Water Solubility
- Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water
- Sensitive
- Light Sensitive
- Stability:
- Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H317
- Precautionary statements
- P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- HS Code
- 29419090
Use
Geldanamycin is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo. 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity. Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer. 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM). 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).
187 supplier list of "17-AAG"
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