Bretazenil suppliers
Bretazenil
- CAS:
- 84379-13-5
- MF:
- C19H20BrN3O3
- MW:
- 418.28
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Properties
- Boiling point:
- 594.3±50.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 24 mg/mL, soluble
- form
- solid
- pka
- 0.78±0.20(Predicted)
- color
- white
- InChI
- InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1
- InChIKey
- LWUDDYHYYNNIQI-ZDUSSCGKSA-N
- SMILES
- N12C=NC(C(OC(C)(C)C)=O)=C1[C@]1([H])CCCN1C(=O)C1=C(Br)C=CC=C12
Safety Information
Use
Bretazenil is an imidazobenzodiazepine partial agonist and a potent anxiolytic. It is rapidly absorbed and has a half-life of 2.5 hours. Animal work has shown that, even after long-term administration of bretazenil, there are no changes in GABA receptor binding or function, and tolerance does not occur. Studies in humans have also suggested that bretazenil has a low abuse potential (Sellers et al. 1991). In terms of clinical effects, bretazenil has demonstrated anxiolytic efficacy in both generalized anxiety disorder and panic disorder (Katschnig et al. 1991), but no controlled study has compared bretazenil with a classic full agonist.
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