Polyinosinic acid manufacturers and suppliers

Polyinosinic acid suppliers

Polyinosinic acid

CAS:: 30918-54-8

MF:: C10H13N4O8P

MW:: 348.21

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Properties

storage temp.: −20°C

solubility: Methanol (Slightly), Water (Sparingly)

form: Solid

color: White to Off-White

InChI: InChI=1/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/s3

InChIKey: GRSZFWQUAKGDAV-BFXIWLNFNA-N

SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,r|

Safety Information

WGK Germany: 3

F: 3-10-21

Use

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I).Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I).Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

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