Aconitine suppliers
Aconitine
- CAS:
- 302-27-2
- MF:
- C34H47NO11
- MW:
- 645.74
Properties
- Melting point:
- 200-205 °C (dec.)
- alpha
- D +17.3° (chloroform)
- Boiling point:
- 675.12°C (rough estimate)
- Density
- 1.2181 (rough estimate)
- refractive index
- 1.6630 (estimate)
- storage temp.
- Refrigerator
- solubility
- Soluble in ethanol;
- form
- White to off-white powder.
- pka
- 5.88(at 25℃)
- color
- White
- optical activity
- +18.224 (c 1.5, CHCl3)
- Water Solubility
- Soluble in ethanol. Sparingly soluble in water
- Merck
- 13,120
- CAS DataBase Reference
- 302-27-2
- NIST Chemistry Reference
- Aconitine(302-27-2)
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H300+H330
- Precautionary statements
- P301+P310+P330-P304+P340+P310
- Hazard Codes
- T+,Xi
- Risk Statements
- 26/28-36/37/38
- Safety Statements
- 24-45-36-26
- RIDADR
- UN 1544 6.1/PG 1
- WGK Germany
- 2
- RTECS
- AR5960000
- F
- 10-34
- HazardClass
- 6.1(a)
- PackingGroup
- I
- Toxicity
- LD50 in mice (mg/kg): 0.166 i.v.; 0.328 i.p.; approx 1 orally (Dybing); also reported as LD50 in mice (mg/kg): 1.8 orally, 0.270 s.c.; 0.380 i.p.; 0.12 i.v. (Sato)
Use
Aconitine is among the most toxic alkaloidsknown. Toxic doses are close to therapeuticdoses, and in humans as little as 2 mgmay cause death (Ferry and Vigneau 1983).An oral lethal dose of 28 mg/kg has alsobeen recorded (NIOSH 1986). The toxicsymptoms at low doses may be excitement,drowsiness, and hypermotility. The first signof poisoning from ingestion is a tingling,burning feeling on the lips, mouth, gums,and throat (Hodgson et al. 1988). This isfollowed by nervous disorders, anesthesia,loss of coordination, vertigo, hypersalivation,nausea, vomiting, and diarrhea. Toxic actionsof aconitine are very rapid. The crystallineform of this compound is much more toxicthan the amorphous aconitine. At a lethaldose, death may result from cardiorespiratoryfailure. Procaine may be an effective antidoteagainst aconitine poisoning.
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