ALCLOFENAC manufacturers and suppliers

ALCLOFENAC suppliers

ALCLOFENAC

CAS:: 22131-79-9

MF:: C11H11ClO3

MW:: 226.66

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Properties

Melting point:: 90-91°C

Boiling point:: 324.6°C (rough estimate)

Density: 1.2401 (rough estimate)

refractive index: 1.4530 (estimate)

storage temp.: Refrigerator

solubility: Chloroform (Slightly), Methanol (Slightly)

pka: pKa 10.3 (Uncertain)

form: Solid

color: Off-White to Pale Yellow

Water Solubility: 13.1mg/L(25 ºC)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P330-P501

Toxicity: LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin)

Use

Alclofenac, a phenylacetic acid derivative with analgesic, antipyretic and antiinflammatory activity, was introduced in 1972 for the treatment of rheumatic disorders. In the late 1970s its use was associated with a high incidence of adverse effects, mainly skin rashes, and a urinary metabolite was reported to have mutagenic activity (positive Ames test). This resulted in the withdrawal of the drug, in some cases voluntarily, from several countries. In others registration has been refused. The reported mutagenic potential has been questioned by some investigators and the drug remains on the market in at least three countries with highly evolved regulatory authorities.

You can find ALCLOFENAC suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.