Amodiaquine manufacturers and suppliers

Amodiaquine suppliers

Properties

Melting point:: 208°C

Boiling point:: 478.0±45.0 °C(Predicted)

Density: 1.258

storage temp.: -20°C Freezer

solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)

form: Solid

pka: 9.43±0.50(Predicted)

color: Pale Yellow to Light Yellow

CAS DataBase Reference: 86-42-0(CAS DataBase Reference)

NIST Chemistry Reference: Amodiaquine(86-42-0)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P330-P501

Hazardous Substances Data: 86-42-0(Hazardous Substances Data)

Toxicity: LD50 oral in mouse: 550mg/kg

Use

Amodiaquine, an antimalarial agent related to chloroquine, was introduced over 40 years ago for the treatment and prophylaxis of malaria. The drug was voluntarily withdrawn in the United Kingdom in 1975 for commercial reasons but was subsequently reintroduced in 1985 to meet the medical demand for an antimalarial drug to deal with the rapid spread of chloroquine-resistant falciparum malaria in Asia and Africa. By 1986 a significant number of cases of agranulocytosis associated with prophylactic use, some of which were fatal, had been reported there and it has been estimated that the frequency of this risk is of the order of 1:2,000. Although most cases occurred when amodiaquine had been used in combination with other antimalarials, the major manufacturer decided to withdraw the prophylactic indication worldwide following discussions with experts. Preparations remain available for the treatment of acute attacks of malaria which involves only a short period of exposure to the drug. (Reference: (WHODI) WHO Drug Information, 1, 5, 1987)

You can find Amodiaquine suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.