AZD-8055 suppliers
AZD-8055
- CAS:
- 1009298-09-2
- MF:
- C25H31N5O4
- MW:
- 465.54
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Properties
- Melting point:
- 204 - 207°C
- Boiling point:
- 694.3±65.0 °C(Predicted)
- Density
- 1.248
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml)
- form
- Yellow powder.
- pka
- 14.20±0.10(Predicted)
- color
- Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H335-H319-H315
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
- Safety Statements
- 24/25
- HS Code
- 29335990
Use
A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S 6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.
137 supplier list of "AZD-8055"