BENZO[A]PYRENE manufacturers and suppliers

Benzo[a]pyrene suppliers

Properties

Melting point:: 177-180°C

Boiling point:: 495°C

Density: 1.1549 (estimate)

vapor pressure: 2.4 at 25 °C (McVeety and Hites, 1988)

refractive index: 1.8530 (estimate)

Flash point:: 495°C

storage temp.: 2-8°C

solubility: Soluble in benzene, toluene, and xylene; sparingly soluble in ethanol and methanol (Windholz et al., 1983)

pka: >15 (Christensen et al., 1975)

form: Crystalline

color: Pale yellow/green/orange

Water Solubility: Soluble in benzene, toluene, and xylene. Sparingly soluble in alcohol, methanol. Insoluble in water

Merck: 14,1103

BRN: 1911333

Henry's Law Constant: 7.35 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)(x 10^-10 mmHg at 25 °C):

Exposure limits: OSHA: TWA 0.2 mg/m3

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: FMMWHPNWAFZXNH-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07,GHS08,GHS09

Signal word: Danger

Hazard statements: H317-H340-H350-H360FD-H410

Precautionary statements: P202-P261-P273-P280-P302+P352-P308+P313

Hazard Codes: T,N,F

Risk Statements: 45-46-50/53-60-61-43-67-66-36-11-65-38-52/53-36/37/38

Safety Statements: 45-53-61-60-26-62-16

RIDADR: 2811

WGK Germany: 3

RTECS: DJ3675000

TSCA: Yes

HazardClass: 6.1

PackingGroup: III

HS Code: 29029090

Toxicity: LD₅₀ for mice (intraperitoneal) 232 mg/kg (Salamone, 1981).

Use

benzo[a]pyrene (BP) is a reasonably potent contact carcinogen, and therefore has been subjected to extensive carcinogenic testing. A diet containing 25 ppm of benzo[a]pyrene (BP) fed to mice for 140 days produced leukemia and lung adenomas in addition to stomach tumors. Skin tumors developed in over 60% of the rats treated topically with approximately 10 mg of benzo[a]pyrene three times per week. The incidence of skin tumors dropped to about 20% when treatment was about 3 mg 3 per week. Above the 10 mg range, however, the incidence of skin tumors increased dramatically to nearly 100%. benzo[a]pyrene (BP) is also carcinogenic when administered orally. In one experiment, weekly doses of greater than 10 mg administered for 10 weeks induced stomach cancers, although no stomach cancers were produced at the dose of 10 mg or less. At 100 mg doses, nearly 79% of the animals had developed stomach tumors by the completion of the experiment. When 15 ppm of benzo[a]pyrene (BP) in feed was orally administered to mice, production of leukemia, lung adenomas, and stomach tumors were observed after 140 days.

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