Bepridil hydrochloride manufacturers and suppliers

Bepridil hydrochloride suppliers

Bepridil hydrochloride

CAS:: 74764-40-2

MF:: C24H37ClN2O2

MW:: 421.01578

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Properties

Melting point:: 91 ±2°

storage temp.: Desiccate at RT

solubility: Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)

form: powder

color: white

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS08,GHS07

Signal word: Danger

Hazard statements: H317-H332-H334

Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P271-P304+P340-P312-P261-P285-P304+P341-P342+P311-P501

WGK Germany: 2

RTECS: UY1162000

Toxicity: LD50 in mice (mg/kg): 1955 orally, 23.5 i.v. (Mauvernay, 1978)

Use

Bepridil hydrochloride,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethylamine hydrochloride (Vascor), is a secondgenerationalkylamine-type channel blocker, structurallyunrelated to the dihydropyridines. Its actions are less specificthan those of the three prototypical channel blockers,verapamil, diltiazem, and nifedipine. In addition to being aCa2+ channel blocker, it inhibits sodium flow into the hearttissue and lengthens cardiac repolarization, causing bradycardia.Caution should be used if it is given to a patient withhypokalemia. Bepridil hydrochloride is used for stableangina. The drug has a half-life of 33 hours and is highlybound to protein (99%).

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