DOMOIC ACID manufacturers and suppliers

DOMOIC ACID suppliers

Properties

Melting point:: 213-217℃

Boiling point:: 451.38°C (rough estimate)

Density: 1.1800 (rough estimate)

refractive index: 1.5130 (estimate)

storage temp.: -20°C

solubility: methanol: 0.6 mg/mL

pka: 2.08±0.60(Predicted)

form: solid

color: white

optical activity: -109.612 (H2O)

Water Solubility: Soluble in water at 8mg/ml. Soluble in methanol at 0.6mg/ml.

Merck: 13,3451

BRN: 46376

Stability:: Light Sensitive

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H302-H370

Precautionary statements: P260-P264-P270-P301+P312-P308+P311-P405

Hazard Codes: Xn

Risk Statements: 20/21/22

Safety Statements: 36/37

WGK Germany: 3

RTECS: UX9665100

Toxicity: An excitory amino acid isolated from the red alga Chondria armata. A structural analog of kainic acid and domoic acid has been shown to be responsible for the shellfish poisoning associated with eating certain cultured blue mussels.

Use

Domoic acid (~300 mg) is purifed on a Dowex1 column (3.5 x 40 mm, 200-400 mesh, acetate form), washed with H2O until neutral, then eluted with increasing concentrations of AcOH (8L) from 0 to 0.25M. The fraction containing domoic acid (in 50mL) is collected, evaporated to dryness under reduced pressure and recrystallised from aqueous EtOH. It is a glutamate and a Kainate receptor agonist. [Impellizzeri et al. Phytochemistry 14 1549 1975, Takemoto & Diago Arch Pharm 293 627 1960, Beilstein 22/4 V 371.]

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