GW1929 suppliers
GW1929
- CAS:
- 196808-24-9
- MF:
- C30H29N3O4
- MW:
- 495.57
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Properties
- Boiling point:
- 749.2±60.0 °C(Predicted)
- Density
- 1.264±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- DMSO: 20 mg/mL
- form
- solid
- pka
- 3.91±0.10(Predicted)
- color
- yellow
- InChIKey
- QTQMRBZOBKYXCG-MHZLTWQESA-N
Safety Information
- WGK Germany
- 3
Use
Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism. The best known class of PPARγ ligands are the thiazolidinediones, including troglitazone and rosiglitazone . GW 1929 is a non-thiazolidinedione activator of PPARγ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes. It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes. Both in vitro and in vivo effects of GW 1929 on PPARγ greatly exceed those produced by troglitazone. In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.[Cayman Chemical]
92 supplier list of "GW1929"