IMD-0354 manufacturers and suppliers

IMD-0354 suppliers

Properties

Boiling point:: 323.1±42.0 °C(Predicted)

Density: 1.561

storage temp.: -20°C

solubility: DMSO (5 mg/ml) or Ethanol (1 mg/ml).

form: White solid

pka: 7.61±0.43(Predicted)

color: White to off-white

Sensitive: Light Sensitive

CAS DataBase Reference: 978-62-1

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

WGK Germany: 3

HS Code: 29242990

Use

IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.

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