L-AP4 manufacturers and suppliers

L-AP4 suppliers

Properties

Melting point:: 207-215 °C

Boiling point:: 491.7±55.0 °C(Predicted)

Density: 1.628±0.06 g/cm3(Predicted)

storage temp.: 0-6°C

solubility: H2O : 50 mg/mL (273.07 mM; Need ultrasonic)

form: solid

pka: 2.19±0.10(Predicted)

color: White

Water Solubility: Soluble to 5 mM in water and to 100 mM in 1eq. NaOH

Sensitive: Light Sensitive

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

WGK Germany: 3

RTECS: ES7191700

Use

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

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