Losartan Carboxaldehyde suppliers
Losartan Carboxaldehyde
- CAS:
- 114798-36-6
- MF:
- C22H21ClN6O
- MW:
- 420.89
Suppliers by country/region
Company Type
Properties
- Melting point:
- 84-86°C
- Boiling point:
- 666.7±65.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.16±0.10(Predicted)
- color
- Off-White to Light Yellow
- CAS DataBase Reference
- 114798-36-6
Safety Information
- HS Code
- 2933290000
Use
Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]
76 supplier list of "Losartan Carboxaldehyde"
- Product Name:Losartan Carboxaldehyde
- Products Intro:Purity: 99.10% | Package: 1mg;31USD|5mg;73USD|10mg;118USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
$0.00/ 10mg
- Product Name:Allisartan Isoproxil Impurity 14
- Products Intro:Purity: 0.98|Package: 10mg;0.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: drug standards,drug impurity reference substances,chemical reagents,in stock