MK-1775 suppliers
MK-1775
- CAS:
- 955365-80-7
- MF:
- C27H32N8O2
- MW:
- 500.6
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Properties
- Melting point:
- 179-181°C
- Boiling point:
- 723.8±70.0 °C(Predicted)
- Density
- 1.292
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (70 mg/ml)
- pka
- 13.27±0.29(Predicted)
- form
- solid
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)
- InChIKey
- BKWJAKQVGHWELA-UHFFFAOYSA-N
- SMILES
- C1(NC2=CC=C(N3CCN(C)CC3)C=C2)=NC=C2C(=O)N(CC=C)N(C3=NC(C(O)(C)C)=CC=C3)C2=N1
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
Use
MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.
165 supplier list of "MK-1775"
- Product Name:MK-1775
- Products Intro:Purity: 98% | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
$7.00/ 1KG
- Product Name:MK-1775
- Products Intro:Purity: 99% | Package: 1KG;7USD
- Company Type: Trader
- Country/Region: CHINA