Nalfurafine suppliers
Nalfurafine
- CAS:
- 152658-17-8
- MF:
- C28H33ClN2O5
- MW:
- 513.02502
Suppliers by country/region
Properties
- Melting point:
- 207-217 °C
- storage temp.
- Store at -20°C
- solubility
- DMF: 16 mg/mL; DMSO: 33 mg/mL; Ethanol: 0.33 mg/mL; PBS (pH 7.2): 5 mg/mL
- form
- A solid
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H336-H302
- Precautionary statements
- P261-P271-P304+P340-P312-P403+P233-P405-P501-P264-P270-P301+P312-P330-P501
Use
Nalfurafine hydrochloride was launched on March of 2009 in Japan as the first in class non-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. A new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.
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