PAROMOMYCIN SULFATE manufacturers and suppliers

PAROMOMYCIN SULFATE suppliers

Properties

Melting point:: 145 °C (decomp)

alpha: D25 +50.5° (c = 1.5 in water pH 6)

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: H₂O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.

form: powder

color: White to Off-White

Water Solubility: Soluble in water

Merck: 14,7041

BRN: 5715182

Stability:: Hygroscopic

InChIKey: LJRDOKAZOAKLDU-UDXJMMFXSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes: Xi

Risk Statements: 23/24/25-36/38-39/23/24/25-61-36/37/38

Safety Statements: 26-36/37-45-38-36

WGK Germany: 2

RTECS: WK2320000

HS Code: 2941901010

Toxicity: LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)

Use

PAROMOMYCIN SULFATE is White to Off-White Solid PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis. The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]

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