Satraplatin manufacturers and suppliers

Satraplatin suppliers

Satraplatin

CAS:: 129580-63-8

MF:: C10H20Cl2N2O4Pt

MW:: 498.26

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Properties

storage temp.: Store at -20°C

solubility: DMF: 0.16 mg/mL; DMSO: 0.5 mg/mL

form: Powder

color: Off-white to yellow

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Toxicity: LD50 in mice (mg/kg): 30 i.p.; 330 orally (Kelland)

Use

Satraplatin (JM216, cis,trans,cis-[PtCl2(OAc)2(NH3)(C6H5NH2)]) is a Pt(IV) or Pt4+ complex, which is active by oral administration, as it is more hydrophobic than cisplatin. This form of administration is very attractive because of the convenience and freedom it provides to the patient. Satraplatin also has a milder toxicity profile and is shows no cross-resistance with cisplatin. Satraplatin in combination with prednisone has completed phase III clinical trials against hormone-refractory prostate cancer. The results were very encouraging, but the overall survival rate did not improve significantly enough. As a result, the fast-track approval of the FDA was not granted.Structurally, satraplatin consists of a Pt(IV) centre, which is coordinated by six ligands forming a close to octahedral geometry. In general, octahedral Pt(IV) complexes (low-spin d6) are much more kinetically inert than square planar Pt(II) complexes.

You can find Satraplatin suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.