Sobuzoxane suppliers
Sobuzoxane
- CAS:
- 98631-95-9
- MF:
- C22H34N4O10
- MW:
- 514.53
Suppliers by country/region
Properties
- Melting point:
- 128-130°; mp 132-133° (Cai, 1989)
- Boiling point:
- 664.9±55.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- solubility
- DMSO: 19 mg/mL
- pka
- 2.75±0.20(Predicted)
- form
- solid
Safety Information
- WGK Germany
- 2
- RTECS
- FG1582500
- Toxicity
- LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa)
Use
Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
19 supplier list of "Sobuzoxane"
-
100mg$840.00
- Product Name:Sobuzoxane
- Products Intro:Brand:Crysdot | Product Number:CD11000920 | Purity:97%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:sobuzoxane
- Products Intro:Brand:ACCEL | Product Number:AT5701 | Purity:97.00%
- Company Type: Trader
- Country/Region: UNITED STATES
-
5MG$719.1025MG$1107.84
- Product Name:SOBUZOXANE
- Products Intro:Brand:Acccorporation | OriginalID:API0008426 | Purity:95.00%
- Company Type: Trader
- Country/Region: UNITED STATES