sorivudine suppliers
sorivudine
- CAS:
- 77181-69-2
- MF:
- C11H13BrN2O6
- MW:
- 349.13
Suppliers by country/region
Properties
- Melting point:
- 182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983)
- alpha
- D25 +0.5° (1N NaOH)
- Density
- 1.979±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (716.07 mM)
- form
- Solid
- pka
- 8.37±0.10(Predicted)
- color
- White to off-white
Safety Information
- Toxicity
- LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984)
Use
Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of 20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream is also useful in the topical treatment of cutaneous HSV-1 infection, including immunocompromised patients. It has been suggested that its antiviral activity may be mediated by inhibition of DNA synthesis in virus infected cells.Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism, caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to avoid hematological disorders.
20 supplier list of "sorivudine"
- Product Name:Sorivudine;BV-araU
- Products Intro:Package: 1 mL * 10mM (in DMSO);10 mg;100 mg;2 mg;25 mg;5 mg;50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
![BRAVAVIR](/images/pro-3.jpg)
-
5MG$501.67
- Product Name:BRAVAVIR
- Products Intro:Brand:Acccorporation | OriginalID:API0007546 | Purity:95.00%
- Company Type: Trader
- Country/Region: UNITED STATES