Teneligliptin suppliers
Teneligliptin
- CAS:
- 760937-92-6
- MF:
- C22H30N6OS
- MW:
- 426.58
Suppliers by country/region
Company Type
Properties
- Melting point:
- >100°C (dec.)
- Boiling point:
- 663.4±55.0 °C(Predicted)
- Density
- 1.38
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 8.70±0.10(Predicted)
- color
- Off-White
- InChIKey
- WGRQANOPCQRCME-PMACEKPBSA-N
- SMILES
- C([C@@H]1C[C@H](N2CCN(C3N(C4=CC=CC=C4)N=C(C)C=3)CC2)CN1)(N1CCSC1)=O
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362
Use
Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM).
143 supplier list of "Teneligliptin"
$1000.00/ 1KG
- Product Name:Teneligliptin
- Products Intro:Purity: 99% | Package: 1KG;1000USD
- Company Type: Reagent
- Country/Region: CHINA
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