Valacyclovir hydrochloride manufacturers and suppliers

Valacyclovir hydrochloride suppliers

Properties

Melting point:: 170-172°C

storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility: H2O: >20mg/mL

form: solid

color: white

λmax: 253nm(H2O)(lit.)

Merck: 14,9899

Stability:: Hygroscopic

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P301+P312+P330

Hazard Codes: Xi,Xn

Risk Statements: 36/37/38-22

Safety Statements: 26-36-24/25

RIDADR: 3077

WGK Germany: 3

HS Code: 29335990

Use

Valacyclovir hydrochloride, an orally active L-valyl ester of the potent antiviral agent aciclovir, was launched in 1995 in the United Kingdom for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent genital herpes. As a prodrug, valaciclovir has an improved pharmacokinetic profile to aciclovir. It is rapidly absorbed after oral administration and extensively converted to aciclovir via first-pass metabolism to achieve plasma levels of aciclovir comparable to those seen with aciclovir via i.v. route. Valacyclovir is then activated selectively in virus-infected cells by viral thymidine kinase to form aciclovir triphosphate in a stepwise fashion. This active species inhibits viral DNA polymerase via irreversible binding to the active site of the enzyme. Once aciclovir is incorporated into the elongating viral DNA, it terminates replication of the viral DNA strand, an antiviral mechanism unique to aciclovir. Valacyclovir is reportedly in clinical trials for the suppression of cytomegalovirus infection and disease in renal transplant patients.

You can find Valacyclovir hydrochloride suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.