Verapamil hydrochloride manufacturers and suppliers

Verapamil hydrochloride suppliers

Properties

Melting point:: 142 °C (dec.)(lit.)

storage temp.: 0-6°C

solubility: methanol: 50 mg/mL, clear, colorless

form: powder

color: white

BCS Class: 1,2

Safety Information

Hazard Codes: T,Xi

Risk Statements: 23/24/25-36/37/38

Safety Statements: 36/37-45-37/39-26

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: YV8320000

F: 8-10

Use

Verapamil hydrochloride (VRP) is a phenylalkylamine calcium ion influx inhibitor (calcium antagonist). Verapamil hydrochloride exerts its pharmacologic effects by modulating the influx of ionic through the slow channels of vascular smooth muscle and cardiac cell membranes. It is widely used for the treatment of hypertension, angina pectoris, supraventricular tachycardia, myocardial infraction, and vascular headaches. Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines The plasma half-life of verapamil hydrochloride is 2–7 hours, which necessitates multiple dosing. After oral administration of VRP to humans, the drug is rapidly absorbed and widely distributed. It is approximately 90% absorbed from the gastrointestinal tract but is subject to considerable first pass metabolism and its bioavailability is around 20–30%. The low bioavailability is owing to the rapid biotransformation in the liver with a biological half-life of 4.0±1.5 hours.

You can find Verapamil hydrochloride suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.