WORTMANNIN manufacturers and suppliers

WORTMANNIN suppliers

Properties

Melting point:: 234-240 °C

alpha: +80.0～+105.0゜(20℃/D)(c=0.1,C2H5OH)

Boiling point:: 463.31°C (rough estimate)

Density: 1.2454 (rough estimate)

refractive index: 1.4480 (estimate)

Flash point:: 2℃

storage temp.: -20°C

solubility: DMSO: soluble

form: powder

color: off-white

biological source: Penicillium funiculosum

Sensitive: Light Sensitive

λmax: 296nm(lit.)

Merck: 14,10053

BRN: 67676

Stability:: Stable for 1 year from date of purchase as supplied. Dried aliquots evaporated from ethanol may be stored at -20° for several months. Solutions however are not stable and must be used within one working day. Note

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300+H310+H330

Precautionary statements: P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310

Hazard Codes: T+,T,Xi,Xn,F

Risk Statements: 26/27/28-36/37/38-36-20/21/22-11

Safety Statements: 28-36/37-45-37/39-26-16

RIDADR: UN 3462 6.1/PG 1

WGK Germany: 3

RTECS: CB9641000

F: 3-8-10

HazardClass: 6.1

PackingGroup: I

HS Code: 29322090

Use

Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumor and antiinflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo.

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