CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
![CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) price.](/CAS/20180713/GIF/CB42705990.gif)
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- $102 - $1481
- Product name: CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
- CAS: 1092776-63-0
- MF: C21H35ClN4S2
- MW: 443.11
- EINECS:
- MDL Number:
- Synonyms:CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2);IT1t dihydrochloride;N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride;CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1;IT1t dihydrochloride,IT-1t dihydrochloride;IT1t (hydrochloride);CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
19 prices
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Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10
- 5mg
- 10mg
- 50
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number3030DC
- Product descriptionIT1tdihydrochloride
- Packaging10mg
- Price$316
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5650
- Product descriptionIT1tdihydrochloride
- Packaging5mg
- Price$134
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5650
- Product descriptionIT1tdihydrochloride
- Packaging10mg
- Price$236
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5650
- Product descriptionIT1tdihydrochloride
- Packaging25mg
- Price$473
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5650
- Product descriptionIT1tdihydrochloride
- Packaging50mg
- Price$851
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5650
- Product descriptionIT1tdihydrochloride
- Packaging100mg
- Price$1481
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28434
- Product descriptionIT1t (hydrochloride)
- Packaging5mg
- Price$110
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28434
- Product descriptionIT1t (hydrochloride)
- Packaging10mg
- Price$195
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28434
- Product descriptionIT1t (hydrochloride)
- Packaging25mg
- Price$459
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6446
- Product descriptionIT1tdihydrochloride 99.97%
- Packaging5mg
- Price$102
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6446
- Product descriptionIT1tdihydrochloride 99.97%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6446
- Product descriptionIT1tdihydrochloride 99.97%
- Packaging25mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6446
- Product descriptionIT1tdihydrochloride 99.97%
- Packaging50mg
- Price$648
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6446
- Product descriptionIT1tdihydrochloride 99.97%
- Packaging100mg
- Price$1128
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10283
- Product descriptionIT1tdihydrochloride >98%
- Packaging250mg
- Price$1100
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4596
- Product descriptionIT1tdihydrochloride ≥99%(HPLC)
- Packaging10
- Price$195
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3030DC | IT1tdihydrochloride | 10mg | $316 | 2021-12-16 | Buy |
| ApexBio Technology | B5650 | IT1tdihydrochloride | 5mg | $134 | 2021-12-16 | Buy |
| ApexBio Technology | B5650 | IT1tdihydrochloride | 10mg | $236 | 2021-12-16 | Buy |
| ApexBio Technology | B5650 | IT1tdihydrochloride | 25mg | $473 | 2021-12-16 | Buy |
| ApexBio Technology | B5650 | IT1tdihydrochloride | 50mg | $851 | 2021-12-16 | Buy |
| ApexBio Technology | B5650 | IT1tdihydrochloride | 100mg | $1481 | 2021-12-16 | Buy |
| Cayman Chemical | 28434 | IT1t (hydrochloride) | 5mg | $110 | 2024-03-01 | Buy |
| Cayman Chemical | 28434 | IT1t (hydrochloride) | 10mg | $195 | 2024-03-01 | Buy |
| Cayman Chemical | 28434 | IT1t (hydrochloride) | 25mg | $459 | 2024-03-01 | Buy |
| ChemScene | CS-6446 | IT1tdihydrochloride 99.97% | 5mg | $102 | 2021-12-16 | Buy |
| ChemScene | CS-6446 | IT1tdihydrochloride 99.97% | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-6446 | IT1tdihydrochloride 99.97% | 25mg | $360 | 2021-12-16 | Buy |
| ChemScene | CS-6446 | IT1tdihydrochloride 99.97% | 50mg | $648 | 2021-12-16 | Buy |
| ChemScene | CS-6446 | IT1tdihydrochloride 99.97% | 100mg | $1128 | 2021-12-16 | Buy |
| DC Chemicals | DC10283 | IT1tdihydrochloride >98% | 250mg | $1100 | 2021-12-16 | Buy |
| Tocris | 4596 | IT1tdihydrochloride ≥99%(HPLC) | 10 | $195 | 2021-12-16 | Buy |
Properties
Melting point :>187° (dec.)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White
Safety Information
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Description
IT1t is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50s = 8 and 11 nM for the human and rat receptors, respectively). It is selective for CXCR4 over human ether-a-go-go-related gene potassium channels (hERG/Kv11.1; IC50 = 13,240 nM). IT1t inhibits calcium mobilization induced by chemokine (C-X-C-motif) ligand 12 (CXCL12) in CEM cells (IC50 = 1.1 nM) and decreases CXCL12-induced migration of Jurkat cells (IC50 = 79.1 nM). It inhibits replication of the HIV-1 strain NL4-3 in MT-4 cells and isolated human peripheral blood mononuclear cells (PBMCs) stimulated with phytohemagglutinin (PHA; IC50s = 14.2 and 19 nM, respectively). IT1t (20 μM) reduces tumor growth in an MDA-MB-231-B zebrafish xenograft model.Suppliers and manufacturers
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Shanghai Lollane Biological Technology Co.,Ltd.
EMMX Biotechnology LLC
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