N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
![N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea price.](/CAS2/GIF/1144068-46-1.gif)
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- $37 - $4462.92
- Product name: N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
- CAS: 1144068-46-1
- MF: C27H33N7O4
- MW: 519.6
- EINECS:
- MDL Number:MFCD22420813
- Synonyms:WYE 125132(WYE-132);1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyriMidin-6-yl)phenyl)-3-Methylurea;WYE125132/WYE-125132/WYE-132;Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl-;N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea WYE125132(WYE-132);WYE 125132 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea;WYE-125132 (WYE-132);WYE-125132;WYE 125132; WYE125132;N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-yl)-1H-pyrazolo[3,4-d
36 prices
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 500μg
- 1MG
- 2mg
- 5MG
- 10mg
- 25mg
- 50MG
- 100mg
- 200MG
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7450
- Product description1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-3-methyl-urea
- Packaging250mg
- Price$1508
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002464
- Product descriptionWYE-125132 95.00%
- Packaging1MG
- Price$191.1
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002464
- Product descriptionWYE-125132 95.00%
- Packaging5MG
- Price$459.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002464
- Product descriptionWYE-125132 95.00%
- Packaging50MG
- Price$2088.36
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002464
- Product descriptionWYE-125132 95.00%
- Packaging200MG
- Price$4462.92
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1642
- Product descriptionWYE-125132(WYE-132)
- Packaging10mg
- Price$239
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1642
- Product descriptionWYE-125132(WYE-132)
- Packaging25mg
- Price$430
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1642
- Product descriptionWYE-125132(WYE-132)
- Packaging50mg
- Price$727
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1642
- Product descriptionWYE-125132(WYE-132)
- Packaging200mg
- Price$1986
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154745
- Product descriptionWYE125132 >98%
- Packaging100mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154745
- Product descriptionWYE125132 >98%
- Packaging250mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154745
- Product descriptionWYE125132 >98%
- Packaging1g
- Price$4023.9
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFW65208
- Product descriptionWYE 125132
- Packaging10mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFW65208
- Product descriptionWYE 125132
- Packaging50mg
- Price$507.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18372
- Product descriptionWYE-125132 ≥98%
- Packaging500μg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18372
- Product descriptionWYE-125132 ≥98%
- Packaging1mg
- Price$62
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7450 | 1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-3-methyl-urea | 250mg | $1508 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002464 | WYE-125132 95.00% | 1MG | $191.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002464 | WYE-125132 95.00% | 5MG | $459.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002464 | WYE-125132 95.00% | 50MG | $2088.36 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002464 | WYE-125132 95.00% | 200MG | $4462.92 | 2021-12-16 | Buy |
| ApexBio Technology | B1642 | WYE-125132(WYE-132) | 10mg | $239 | 2021-12-16 | Buy |
| ApexBio Technology | B1642 | WYE-125132(WYE-132) | 25mg | $430 | 2021-12-16 | Buy |
| ApexBio Technology | B1642 | WYE-125132(WYE-132) | 50mg | $727 | 2021-12-16 | Buy |
| ApexBio Technology | B1642 | WYE-125132(WYE-132) | 200mg | $1986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154745 | WYE125132 >98% | 100mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154745 | WYE125132 >98% | 250mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154745 | WYE125132 >98% | 1g | $4023.9 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FW65208 | WYE 125132 | 10mg | $145 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FW65208 | WYE 125132 | 50mg | $507.5 | 2021-12-16 | Buy |
| Cayman Chemical | 18372 | WYE-125132 ≥98% | 500μg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 18372 | WYE-125132 ≥98% | 1mg | $62 | 2024-03-01 | Buy |
Properties
Melting point :162-184°C (dec.)
Density :1.55
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :White powder solid.
pka :13.82±0.46(Predicted)
color :Off-White to Pale Beige
Density :1.55
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :White powder solid.
pka :13.82±0.46(Predicted)
color :Off-White to Pale Beige
Safety Information
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Description
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0.19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.More related product prices
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![N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea](https://img.chemicalbook.com/ProductImageEN/2018-12/small/fe498182-1055-4d7c-bbd5-8bbb37f80631.png){kind=small}