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ChemicalBook >> CAS DataBase List >> 4-oxo-27-TBDMS Withaferin A

4-oxo-27-TBDMS Withaferin A

4-oxo-27-TBDMS Withaferin A price.
  • $81 - $396
  • Product name: 4-oxo-27-TBDMS Withaferin A
  • CAS: 1214886-31-3
  • MF: C34H50O6Si
  • MW: 582.85
  • EINECS:
  • MDL Number:
  • Synonyms:4-oxo-27-TBDMS Withaferin A;Ergosta-2,24-dien-26-oic acid, 27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6-epoxy-22-hydroxy-1,4-dioxo-, δ-lactone, (5β,6β,22R)-;(5β,6β,22R)-27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6-epoxy-22-hydroxy-1,4-dioxo-ergosta-2,24-dien-26-oic acid, δ-lactone
Price3 Properties Safety Information Description
3 prices
Selected condition：
Brand
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • ManufacturerCayman Chemical
  • Product number28323
  • Product description4-oxo-27-TBDMS Withaferin A
  • Packaging1mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28323
  • Product description4-oxo-27-TBDMS Withaferin A
  • Packaging5mg
  • Price$238
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28323
  • Product description4-oxo-27-TBDMS Withaferin A
  • Packaging10mg
  • Price$396
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 28323 4-oxo-27-TBDMS Withaferin A 1mg $81 2024-03-01 Buy
Cayman Chemical 28323 4-oxo-27-TBDMS Withaferin A 5mg $238 2024-03-01 Buy
Cayman Chemical 28323 4-oxo-27-TBDMS Withaferin A 10mg $396 2024-03-01 Buy

Properties

Boiling point :651.3±55.0 °C(Predicted)
Density :1.14±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 5mg/mL; DMSO: 5mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Description

4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.

Suppliers and manufacturers

Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Changzhou Furuisi Biotechnology Co., Ltd Beijing Biocreative Technology Co., Ltd. Shanghai Yiyan Biotechnology Co. , Ltd. Shanghai Yifei Biotechnology Co. , Ltd. TargetMol Chemicals Inc.