6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
![6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one price.](/CAS/GIF/1221186-53-3.gif)
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- $47 - $3200
- Product name: 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
- CAS: 1221186-53-3
- MF: C17H16N4O2S2
- MW: 372.46
- EINECS:
- MDL Number:MFCD23160747
- Synonyms:6-[(3-Aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[;6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one;6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-on;2-methylsulfinyl-4-methyl-6-[(3-aminophenyl)methyl]-4H-thieno[3,2-b]pyrrole[3,2-d]pyridazinone;]dodeca-1(8),2(6),4,11-tetraen-9-one;10-[(3-aminophenyl)methyl]-7-methyl-4-methylsulfinyl-3-thia-7,10,11-triazatricyclo[6.4.0.0<Name: 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one;TEPP 46 - ML 265
28 prices
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Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3687-M005
- Product descriptionTEPP46[ML-265] ≥95%
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3687-M025
- Product descriptionTEPP46[ML-265] ≥95%
- Packaging25mg
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2952DF
- Product description6-[(3-Aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone
- Packaging5mg
- Price$237
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4181
- Product descriptionML-265
- Packaging5mg
- Price$112
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4181
- Product descriptionML-265
- Packaging10mg
- Price$184
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4181
- Product descriptionML-265
- Packaging25mg
- Price$356
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2240
- Product descriptionTEPP46-ML265 99%
- Packaging5mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2240
- Product descriptionTEPP46-ML265 99%
- Packaging2x25mg
- Price$528
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT161418
- Product descriptionTEPP-46
- Packaging5mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT161418
- Product descriptionTEPP-46
- Packaging10mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT161418
- Product descriptionTEPP-46
- Packaging25mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT161418
- Product descriptionTEPP-46
- Packaging50mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT161418
- Product descriptionTEPP-46
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13942
- Product descriptionML-265 ≥95%
- Packaging1mg
- Price$47
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13942
- Product descriptionML-265 ≥95%
- Packaging5mg
- Price$127
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13942
- Product descriptionML-265 ≥95%
- Packaging10mg
- Price$206
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3687-M005 | TEPP46[ML-265] ≥95% | 5mg | $95 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3687-M025 | TEPP46[ML-265] ≥95% | 25mg | $325 | 2021-12-16 | Buy |
| AK Scientific | 2952DF | 6-[(3-Aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone | 5mg | $237 | 2021-12-16 | Buy |
| ApexBio Technology | C4181 | ML-265 | 5mg | $112 | 2021-12-16 | Buy |
| ApexBio Technology | C4181 | ML-265 | 10mg | $184 | 2021-12-16 | Buy |
| ApexBio Technology | C4181 | ML-265 | 25mg | $356 | 2021-12-16 | Buy |
| Axon Medchem | Axon2240 | TEPP46-ML265 99% | 5mg | $99 | 2021-12-16 | Buy |
| Axon Medchem | Axon2240 | TEPP46-ML265 99% | 2x25mg | $528 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT161418 | TEPP-46 | 5mg | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT161418 | TEPP-46 | 10mg | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT161418 | TEPP-46 | 25mg | $400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT161418 | TEPP-46 | 50mg | $500 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT161418 | TEPP-46 | 100mg | $600 | 2021-12-16 | Buy |
| Cayman Chemical | 13942 | ML-265 ≥95% | 1mg | $47 | 2024-03-01 | Buy |
| Cayman Chemical | 13942 | ML-265 ≥95% | 5mg | $127 | 2024-03-01 | Buy |
| Cayman Chemical | 13942 | ML-265 ≥95% | 10mg | $206 | 2024-03-01 | Buy |
Properties
Boiling point :711.6±70.0 °C(Predicted)
Density :1.58±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥37.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :A crystalline solid
pka :4.33±0.10(Predicted)
color :White to light yellow
Density :1.58±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥37.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :A crystalline solid
pka :4.33±0.10(Predicted)
color :White to light yellow
Safety Information
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Description
Pyruvate kinase catalyzes the final step in glycolysis, the formation of pyruvate and ATP from phosphoenolpyruvate and ADP. The expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in the metabolic reprogramming of tumor cells, which require high amounts of glucose for proliferation. PKM2 is allosterically regulated by the upstream glycolytic intermediate, fructose-1,6-bisphosphate (FBP), which controls glycolysis in a feed forward mechanism. Whereas cancer cells exist in highly phosphorylated states, the binding of certain peptide motifs with phosphorylated tyrosines can inhibit PKM2 activity by causing the release of FBP from the allosteric site. ML-265 activates tumor-specific PKM2 (EC50 = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization, which is the most active form of the enzyme. It demonstrates >100-fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms. At 50 mg/kg, ML-265 has been shown to reduce tumor size, weight, and occurrence in mice bearing H1299 cell xenografts in a model of human non-small cell lung carcinoma.Suppliers and manufacturers
Shanghai UCHEM Inc.
![6-(3-Aminobenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one](/ProductImageEN/2023-12/small/e8cc6b90-d0f4-46ae-9808-0c2759892305.png)
ATK CHEMICAL COMPANY LIMITED
Fuxin Pharmaceutical
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Finetech Industry Limited
CD Chemical Group Limited
Nextpeptide Inc
InvivoChem
$668.00 /1g
6-(3-Aminobenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one CAS:1221186-53-3
6-(3-Aminobenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one CAS:1221186-53-3
![Name: 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one](https://img.chemicalbook.com/ProductImageEN/2020-1/small/32d4ad3b-2aeb-4a81-8bff-f5956bcedf79.jpg){kind=small}