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ChemicalBook >> CAS DataBase List >>6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one Structure
6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one structure
CAS No.
1221186-53-3
Chemical Name:
6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
Synonyms
ML265;TEPP-46;CS-2036;ML 265;ML265;ML-265 TEPP-46;ML-265(TEPP-46);TEPP 46 - ML 265;3-dihydroxy-quinoxalin;4,5]pyrrolo[2,3-d]pyridazin-5-one;]dodeca-1(8),2(6),4,11-tetraen-9-one
CBNumber:
CB62603704
Molecular Formula:
C17H16N4O2S2
Molecular Weight:
372.46
MDL Number:
MFCD23160747
MOL File:
1221186-53-3.mol
Last updated:2024-07-02 08:55:13
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6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one Properties

Boiling point 711.6±70.0 °C(Predicted)
Density 1.58±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥37.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form A crystalline solid
pka 4.33±0.10(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 505487 PKM2 Activator IV, TEPP-46 - Calbiochem PKM2 Activator IV, TEPP-46, CAS 1221186-53-3, is a cell-permeable, allosteric PKM2 activator (AC50 = 92 nM) that stabilizes PKM2 tetramer via stoichiometric interaction with FBP-bound PKM2. 1221186-53-3 5MG $280 2024-03-01 Buy
Cayman Chemical 13942 ML-265 ≥95% 1221186-53-3 1mg $47 2024-03-01 Buy
Cayman Chemical 13942 ML-265 ≥95% 1221186-53-3 5mg $127 2024-03-01 Buy
Cayman Chemical 13942 ML-265 ≥95% 1221186-53-3 10mg $206 2024-03-01 Buy
Cayman Chemical 13942 ML-265 ≥95% 1221186-53-3 25mg $395 2024-03-01 Buy
Product number Packaging Price Buy
505487 5MG $280 Buy
13942 1mg $47 Buy
13942 5mg $127 Buy
13942 10mg $206 Buy
13942 25mg $395 Buy

6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one Chemical Properties,Uses,Production

Description

Pyruvate kinase catalyzes the final step in glycolysis, the formation of pyruvate and ATP from phosphoenolpyruvate and ADP. The expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in the metabolic reprogramming of tumor cells, which require high amounts of glucose for proliferation. PKM2 is allosterically regulated by the upstream glycolytic intermediate, fructose-1,6-bisphosphate (FBP), which controls glycolysis in a feed forward mechanism. Whereas cancer cells exist in highly phosphorylated states, the binding of certain peptide motifs with phosphorylated tyrosines can inhibit PKM2 activity by causing the release of FBP from the allosteric site. ML-265 activates tumor-specific PKM2 (EC50 = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization, which is the most active form of the enzyme. It demonstrates >100-fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms. At 50 mg/kg, ML-265 has been shown to reduce tumor size, weight, and occurrence in mice bearing H1299 cell xenografts in a model of human non-small cell lung carcinoma.

Uses

6-[(3-Aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one is a pyruvate kinase M2 (PKM2) activator. It regulates lipid homeostasis in cancer cells and reverses aggressive cancer phenotypes.

Definition

ChEBI: 6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone is an organosulfur heterocyclic compound, an organonitrogen heterocyclic compound and an organic heterobicyclic compound.

storage

Store at -20°C

References

[1]. anastasiou d, yu y, israelsen wj, et al. pyruvate kinase m2 activators promote tetramer formation and suppress tumorigenesis. nat chem biol. 2012 oct;8(10):839-47.
[2]. walsh mj, brimacombe kr, anastasiou d, et al. ml265: a potent pkm2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model. probe reports from the nih molecular libraries program [internet].

6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one Suppliers

Global( 114)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 6870 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10297 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21149 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9626 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20356 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19915 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
Shanghai UCHEM Inc. 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Finetech Industry Limited 		58
CD Chemical Group Limited 		58
Nextpeptide Inc 		58
InvivoChem 		58

View Lastest Price from 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-(3-Aminobenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one pictures 2024-02-23 6-(3-Aminobenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one
1221186-53-3
 US $668.00 / g 1g 0.97 1kg Shanghai UCHEM Inc.
6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one pictures 2022-09-27 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
1221186-53-3
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Name: 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one pictures 2020-01-09 Name: 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
1221186-53-3
 US $5.50 / KG 1KG 98%min 1kg-100kg Career Henan Chemical Co

6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one Spectrum

6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one(1221186-53-3)1HNMR
6-[(3-Aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[ 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-on 2-methylsulfinyl-4-methyl-6-[(3-aminophenyl)methyl]-4H-thieno[3,2-b]pyrrole[3,2-d]pyridazinone ]dodeca-1(8),2(6),4,11-tetraen-9-one 10-[(3-aminophenyl)methyl]-7-methyl-4-methylsulfinyl-3-thia-7,10,11-triazatricyclo[6.4.0.0< Name: 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one TEPP 46 - ML 265 CS-2036 ML 265;ML265 ML-265 TEPP-46 ML-265(TEPP-46) TEPP-46(ML265,CID-44246499,NCGC00186528) 4,5]pyrrolo[2,3-d]pyridazin-5-one 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3' 7-(3-aminobenzyl)-4-methyl-2-(methylsulfinyl)-4,7-dihydro-8H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-8-one 5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one, 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)- 3-dihydroxy-quinoxalin TEPP-46 ML265 10-[(3-aminophenyl)methyl]-7-methyl-4-methylsulfinyl-3-thia-7,10,11-triazatricyclo[6.4.0.02?]dodeca-1(8),2(6),4,11-tetraen-9-one 6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinylthieno[3,4]pyrrolo[1,3-d]pyridazin-5-one 6-(3-Aminobenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one 6-(3-Aminobenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one 6-[(3-aMinophenyl)Methyl]-4,6-dihydro-4-Methyl-2-(Methylsulfinyl)-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1221186-53-3