N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
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- $32 - $2200
- Product name: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
- CAS: 1346572-63-1
- MF: C31H38N6O2
- MW: 526.67
- EINECS:-0
- MDL Number:MFCD28405142
- Synonyms:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide;GSK503;GSK03;GSK-503,EZH2 inhibitor;N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide;1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-;CS-1698;GSK-503;GSK 503
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Brand
- AK Scientific
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product number3708AH
- Product descriptionN-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
- Packaging10mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3708AH
- Product descriptionN-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
- Packaging50mg
- Price$556
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5833
- Product descriptionGSK503
- Packaging10mM(in 1mL DMSO)
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFG137681
- Product descriptionGSK 503
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFG137681
- Product descriptionGSK 503
- Packaging50mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18531
- Product descriptionGSK503 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18531
- Product descriptionGSK503 ≥98%
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18531
- Product descriptionGSK503 ≥98%
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18531
- Product descriptionGSK503 ≥98%
- Packaging25mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-4179
- Product descriptionGSK503 99.73%
- Packaging5mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4179
- Product descriptionGSK503 99.73%
- Packaging10mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4179
- Product descriptionGSK503 99.73%
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4179
- Product descriptionGSK503 99.73%
- Packaging100mg
- Price$960
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003799
- Product descriptionGSK503 98+%
- Packaging50mg
- Price$568
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003799
- Product descriptionGSK503 98+%
- Packaging100mg
- Price$965
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8044
- Product descriptionGSK503 >98%
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3708AH | N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide | 10mg | $218 | 2021-12-16 | Buy |
| AK Scientific | 3708AH | N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide | 50mg | $556 | 2021-12-16 | Buy |
| ApexBio Technology | B5833 | GSK503 | 10mM(in 1mL DMSO) | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FG137681 | GSK 503 | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FG137681 | GSK 503 | 50mg | $375 | 2021-12-16 | Buy |
| Cayman Chemical | 18531 | GSK503 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18531 | GSK503 ≥98% | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 18531 | GSK503 ≥98% | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 18531 | GSK503 ≥98% | 25mg | $456 | 2024-03-01 | Buy |
| ChemScene | CS-4179 | GSK503 99.73% | 5mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-4179 | GSK503 99.73% | 10mg | $156 | 2021-12-16 | Buy |
| ChemScene | CS-4179 | GSK503 99.73% | 50mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-4179 | GSK503 99.73% | 100mg | $960 | 2021-12-16 | Buy |
| Crysdot | CD31003799 | GSK503 98+% | 50mg | $568 | 2021-12-16 | Buy |
| Crysdot | CD31003799 | GSK503 98+% | 100mg | $965 | 2021-12-16 | Buy |
| DC Chemicals | DC8044 | GSK503 >98% | 100mg | $650 | 2021-12-16 | Buy |
Properties
Boiling point :798.6±60.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥21.65 mg/mL in DMSO; insoluble in H2O; ≥26.85 mg/mL in EtOH with gentle warming
form :solid
pka :11.93±0.10(Predicted)
color :White to gray
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥21.65 mg/mL in DMSO; insoluble in H2O; ≥26.85 mg/mL in EtOH with gentle warming
form :solid
pka :11.93±0.10(Predicted)
color :White to gray
Safety Information
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Description
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) and is involved in proliferation and aggressive cell growth associated with neoplastic cells. GSK503 is an inhibitor of EZH2 that prevents the methyltransferase activity of wild-type and mutant EZH2 with similar potency (Kiapp = 3-27 nM). It is more than 200-fold selective for EZH2 over EZH1 and more than 4,000-fold selective over other histone methyltransferases. GSK503 displays favorable pharmacokinetics in mice. It prevents germinal center formation and hyperplasia that is relevant to lymphoma generation and inhibits growth and metastasis of cutaneous melanomas in mice.Related product price
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