GSK461364
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- $34 - $3990
- Product name: GSK461364
- CAS: 929095-18-1
- MF: C27H28F3N5O2S
- MW: 543.6
- EINECS:200-258-5
- MDL Number:MFCD12755419
- Synonyms:(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide;GSK-461364A;GSK461364(GSK-461364);5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl];5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phen;GSK461364;GSK-461364;GSK4613
29 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 2.5mg
- 5MG
- 10mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 200mg
- 250mg
- 1G
- ManufacturerAK Scientific
- Product numberX7374
- Product description5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide
- Packaging250mg
- Price$2474
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000326
- Product description5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00%
- Packaging5MG
- Price$598
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000326
- Product description5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00%
- Packaging1G
- Price$3240
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8441
- Product descriptionGSK461364
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60399
- Product descriptionGSK461364 ≥98%
- Packaging5mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1688
- Product descriptionGSK461364 99%
- Packaging5mg
- Price$115.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1688
- Product descriptionGSK461364 99%
- Packaging2x25mg
- Price$594
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM43315
- Product descriptionGSK 461364
- Packaging10mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM43315
- Product descriptionGSK 461364
- Packaging50mg
- Price$612.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18099
- Product descriptionGSK461364 ≥95%
- Packaging1mg
- Price$34
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18099
- Product descriptionGSK461364 ≥95%
- Packaging5mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18099
- Product descriptionGSK461364 ≥95%
- Packaging10mg
- Price$216
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18099
- Product descriptionGSK461364 ≥95%
- Packaging25mg
- Price$493
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM161276
- Product description5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide 98%
- Packaging100mg
- Price$393
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0069
- Product descriptionGSK461364 99.82%
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0069
- Product descriptionGSK461364 99.82%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7374 | 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide | 250mg | $2474 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000326 | 5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00% | 5MG | $598 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000326 | 5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00% | 1G | $3240 | 2021-12-16 | Buy |
| ApexBio Technology | A8441 | GSK461364 | 10mg | $150 | 2021-12-16 | Buy |
| Arctom | CFN60399 | GSK461364 ≥98% | 5mg | $188 | 2021-12-16 | Buy |
| Axon Medchem | Axon1688 | GSK461364 99% | 5mg | $115.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon1688 | GSK461364 99% | 2x25mg | $594 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM43315 | GSK 461364 | 10mg | $175 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM43315 | GSK 461364 | 50mg | $612.5 | 2021-12-16 | Buy |
| Cayman Chemical | 18099 | GSK461364 ≥95% | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 18099 | GSK461364 ≥95% | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 18099 | GSK461364 ≥95% | 10mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 18099 | GSK461364 ≥95% | 25mg | $493 | 2024-03-01 | Buy |
| Chemenu | CM161276 | 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide 98% | 100mg | $393 | 2021-12-16 | Buy |
| ChemScene | CS-0069 | GSK461364 99.82% | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0069 | GSK461364 99.82% | 10mg | $150 | 2021-12-16 | Buy |
Properties
Melting point :>150°C (dec.)
Boiling point :658.0±65.0 °C(Predicted)
Density :1.39
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :15.16±0.50(Predicted)
form :Solid
color :Off-White to Light Beige
Boiling point :658.0±65.0 °C(Predicted)
Density :1.39
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :15.16±0.50(Predicted)
form :Solid
color :Off-White to Light Beige
Safety Information
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Description
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. GSK461364 is a potent, reversible inhibitor of Plk1 (Ki = 2.2 nM). It is less effective against Plk2 and Plk3 (Kis = 860 and 1,000 nM, respectively) and at least 1,000-fold selective for Plk1 over a panel of 48 other kinases. GSK461364 dose-dependently halts cell cycling in diverse proliferating cancer cell lines and, at higher doses, triggers apoptosis. It appears to be more effective against p53-deficient tumors and is able to cross the blood-brain barrier. GSK461364 is effective in vivo, inducing tumor growth inhibition or growth delay in xenograft models in mice.Related product price
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