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ChemicalBook >> CAS DataBase List >> 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone price.
  • $62 - $620
  • Product name: 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
  • CAS: 1402830-75-4
  • MF: C25H19NO3
  • MW: 381.42326
  • EINECS:802-692-7
  • MDL Number:MFCD25977826
  • Synonyms:3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone;3-[3-(4-Methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone;2(1H)-Quinolinone, 3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-;Ceranib-2 >=98% (HPLC)
Price11 Properties Safety Information Description
11 prices
Selected condition：
Brand
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerApexBio Technology
  • Product numberC3649
  • Product descriptionCeranib-2
  • Packaging10mg
  • Price$129
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11092
  • Product descriptionCeranib-2 ≥98%
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11092
  • Product descriptionCeranib-2 ≥98%
  • Packaging10mg
  • Price$115
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11092
  • Product descriptionCeranib-2 ≥98%
  • Packaging25mg
  • Price$270
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11092
  • Product descriptionCeranib-2 ≥98%
  • Packaging50mg
  • Price$477
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064152
  • Product descriptionCeranib-2 99.25%
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064152
  • Product descriptionCeranib-2 99.25%
  • Packaging25mg
  • Price$230
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064152
  • Product descriptionCeranib-2 99.25%
  • Packaging50mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0064152
  • Product descriptionCeranib-2 99.25%
  • Packaging100mg
  • Price$620
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0607
  • Product descriptionCeranib-2 ≥98% (HPLC)
  • Packaging5mg
  • Price$93.9
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0607
  • Product descriptionCeranib-2 ≥98% (HPLC)
  • Packaging25mg
  • Price$361
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology C3649 Ceranib-2 10mg $129 2021-12-16 Buy
Cayman Chemical 11092 Ceranib-2 ≥98% 5mg $62 2024-03-01 Buy
Cayman Chemical 11092 Ceranib-2 ≥98% 10mg $115 2024-03-01 Buy
Cayman Chemical 11092 Ceranib-2 ≥98% 25mg $270 2024-03-01 Buy
Cayman Chemical 11092 Ceranib-2 ≥98% 50mg $477 2024-03-01 Buy
ChemScene CS-0064152 Ceranib-2 99.25% 10mg $110 2021-12-16 Buy
ChemScene CS-0064152 Ceranib-2 99.25% 25mg $230 2021-12-16 Buy
ChemScene CS-0064152 Ceranib-2 99.25% 50mg $380 2021-12-16 Buy
ChemScene CS-0064152 Ceranib-2 99.25% 100mg $620 2021-12-16 Buy
Sigma-Aldrich SML0607 Ceranib-2 ≥98% (HPLC) 5mg $93.9 2024-03-01 Buy
Sigma-Aldrich SML0607 Ceranib-2 ≥98% (HPLC) 25mg $361 2024-03-01 Buy

Properties

storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Ceramidase catalyzes the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. It plays a critical role in regulating cell fate and its inhibition in both malignant and non-cancerous cells leads to apoptosis. Ceranib-2 is a non-lipid inhibitor of cellular ceramidase activity that demonstates an IC50 of 28 μM in a cell-based assay. At 3.125 μM, Ceranib-2 increased the accumulation of endogenous ceramide species by 109% compared to controls and dose-dependently decreased intracellular levels of sphingosine and sphingosine-1-phosphate. Ceranib-2 inhibited cell proliferation of SKOV3 ovarian cancer cells with an IC50 value of 0.71 μM and had additive effects on cell proliferation when combined with paclitaxel. In vivo, Ceranib-2 at 20-50 mg/kg supresses tumor growth in a syngeneic tumor model without noticeable toxicity.

Suppliers and manufacturers

TargetMol Chemicals Inc.
LEAPCHEM CO., LTD.
Aladdin Scientific DKMbiochem.Co. Ltd BOC Sciences Beijing Jin Ming Biotechnology Co., Ltd. ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc Energy Chemical Beijing Jin Ming Biotechnology Co., Ltd.