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ChemicalBook >> CAS DataBase List >> (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-

(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-

$36 - $1802
Product name: (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-
CAS: 1421919-75-6
MF: C16H10F8N4O
MW: 426.26
EINECS:-0
MDL Number:MFCD27937049
Synonyms:(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-;KPT-276;2-Propen-1-one, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-, (2Z)-;(KPT276)(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one;KPT276; KPT 276;(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one;CS-1100;(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3- USP/EP/BP

Price17 Properties Safety Information Description

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Brand

Ambeed
ApexBio Technology
Biorbyt Ltd
Cayman Chemical
Crysdot
DC Chemicals

Package

5mg
10mg
25mg
50mg
100mg
250mg
1g
1000mg

ManufacturerAmbeed
Product numberA192347
Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
Packaging5mg
Price$36
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA192347
Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
Packaging10mg
Price$61
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA192347
Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
Packaging50mg
Price$168
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA192347
Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
Packaging100mg
Price$286
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA192347
Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
Packaging250mg
Price$572
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA192347
Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
Packaging1g
Price$1745
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberB1463
Product descriptionKPT-276
Packaging10mg
Price$68
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB1463
Product descriptionKPT-276
Packaging50mg
Price$189
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb180987
Product descriptionKPT-276 >98%
Packaging100mg
Price$606.9
Updated2021-12-16
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ManufacturerBiorbyt Ltd
Product numberorb180987
Product descriptionKPT-276 >98%
Packaging250mg
Price$912.9
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb180987
Product descriptionKPT-276 >98%
Packaging1000mg
Price$1802
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number29158
Product descriptionKPT-276
Packaging5mg
Price$68
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number29158
Product descriptionKPT-276
Packaging10mg
Price$109
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number29158
Product descriptionKPT-276
Packaging25mg
Price$201
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number29158
Product descriptionKPT-276
Packaging50mg
Price$268
Updated2024-03-01
Buy

ManufacturerCrysdot
Product numberCD31003540
Product descriptionKPT-276 98+%
Packaging50mg
Price$222
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Ambeed	A192347	(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%	5mg	$36	2021-12-16	Buy
Ambeed	A192347	(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%	10mg	$61	2021-12-16	Buy
Ambeed	A192347	(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%	50mg	$168	2021-12-16	Buy
Ambeed	A192347	(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%	100mg	$286	2021-12-16	Buy
Ambeed	A192347	(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%	250mg	$572	2021-12-16	Buy
Ambeed	A192347	(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%	1g	$1745	2021-12-16	Buy
ApexBio Technology	B1463	KPT-276	10mg	$68	2021-12-16	Buy
ApexBio Technology	B1463	KPT-276	50mg	$189	2021-12-16	Buy
Biorbyt Ltd	orb180987	KPT-276 >98%	100mg	$606.9	2021-12-16	Buy
Biorbyt Ltd	orb180987	KPT-276 >98%	250mg	$912.9	2021-12-16	Buy
Biorbyt Ltd	orb180987	KPT-276 >98%	1000mg	$1802	2021-12-16	Buy
Cayman Chemical	29158	KPT-276	5mg	$68	2024-03-01	Buy
Cayman Chemical	29158	KPT-276	10mg	$109	2024-03-01	Buy
Cayman Chemical	29158	KPT-276	25mg	$201	2024-03-01	Buy
Cayman Chemical	29158	KPT-276	50mg	$268	2024-03-01	Buy
Crysdot	CD31003540	KPT-276 98+%	50mg	$222	2021-12-16	Buy

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Properties

Boiling point :477.2±55.0 °C(Predicted)
Density :1.56±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥19.85 mg/mL in DMSO
form :solid
pka :0.59±0.50(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

KPT-276 is an orally bioavailable inhibitor of Exportin 1 (XPO1/CRM1) with anticancer activity. In vivo, KPT-276 (150 mg/kg) increases survival and reduces spleen weight and white blood cell count in an MV4-11 acute myeloid leukemia (AML) mouse xenograft model. It also reduces tumor volume and increases survival in a BT 145 glioblastoma mouse xenograft model when administered at a dose of 75 mg/kg.

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Suppliers and manufacturers

career henan chemical co

$1.00 /1KG
(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one CAS:1421919-75-6

ATK CHEMICAL COMPANY LIMITED

Hubei Jusheng Technology Co.,Ltd.

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Dideu Industries Group Limited

Zhejiang J&C Biological Technology Co.,Limited

CD Chemical Group Limited

InvivoChem

LEAP CHEM CO., LTD.

TargetMol Chemicals Inc.

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(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-

Properties

Safety Information

Description

Related product price

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