5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
- $265 - $757.97
- Product name: 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
- CAS: 145915-60-2
- MF: C20H13F2N3O2
- MW: 365.33
- EINECS:
- MDL Number:MFCD00938569
- Synonyms:CGP 53353;5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE;5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE;5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2;DAPH 2;DAPH-7;PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem;1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
6 prices
Selected condition:
Brand
- American Custom Chemicals Corporation
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 2mg
- 2.5mg
- 5mg
- 10MG
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000185
- Product description5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE 95.00%
- Packaging10MG
- Price$757.97
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number539652
- Product descriptionCGP-53353 The PKC
- Packaging2mg
- Price$272
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberC7866
- Product descriptionCGP-53353 solid
- Packaging5mg
- Price$313
- Updated2022-05-15
- Buy
- ManufacturerTocris
- Product number2442
- Product descriptionCGP53353 ≥99%(HPLC)
- Packaging10
- Price$265
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberC583575
- Product descriptionCGP53353
- Packaging2.5mg
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number254940
- Product descriptionCGP 53353
- Packaging10mg
- Price$531
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
American Custom Chemicals Corporation | INB0000185 | 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE 95.00% | 10MG | $757.97 | 2021-12-16 | Buy |
Sigma-Aldrich | 539652 | CGP-53353 The PKC | 2mg | $272 | 2024-03-01 | Buy |
Sigma-Aldrich | C7866 | CGP-53353 solid | 5mg | $313 | 2022-05-15 | Buy |
Tocris | 2442 | CGP53353 ≥99%(HPLC) | 10 | $265 | 2021-12-16 | Buy |
TRC | C583575 | CGP53353 | 2.5mg | $325 | 2021-12-16 | Buy |
Usbiological | 254940 | CGP 53353 | 10mg | $531 | 2021-12-16 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :solid
color :orange
solubility :DMSO: >10mg/mL
form :solid
color :orange
Safety Information
Symbol(GHS): | ||||||||
---|---|---|---|---|---|---|---|---|
Signal word: | ||||||||
Hazard statements: |
|
|||||||
Precautionary statements: |
|
Description
DAPH-7 is a highly selective procarcinogenic protein kinase C-βII (PKCβII) inhibitor that can also inhibit nPKCs and aPKCs, and upregulate VCAM-1, in a dose dependent manner. The compound has been shown to inhibit a variety of kinases, such as, protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM. Studies show that inhibitory DAPHs can reconstruct Sup35 prion-specific intermolecular interfaces to create morphologically altered aggregates with diminished infectivity and self-templating activity. When DAPHs alter the folding of Sup35s amyloidogenic core it blocks amyloidogenic oligomerization and specific recognition events that nucleate prion assembly. Research shows that DAPH-7, also known as, CGP-53353, can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells.More related product prices
3,4-DimethyldiphenylamineRelated product price
- 3,4-Dimethyldiphenylamine
$8-2573.34 - 4,5-DIANILINOPHTHALIMIDE
$160-1105.42 - 145915-60-2
$265-757.97
Suppliers and manufacturers
TargetMol Chemicals Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Aladdin Scientific
3B Pharmachem (Wuhan) International Co.,Ltd.
EMMX Biotechnology LLC
Shanghai Rechem science Co., Ltd.
Changzhou Chenhong Biotechnology Co., Ltd.
Energy Chemical
MedBioPharmaceutical Technology Inc
Changzhou Furuisi Biotechnology Co., Ltd