5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
![5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE price.](/CAS/GIF/145915-60-2.gif)
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- $265 - $757.97
- Product name: 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
- CAS: 145915-60-2
- MF: C20H13F2N3O2
- MW: 365.33
- EINECS:
- MDL Number:MFCD00938569
- Synonyms:CGP 53353;5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE;5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE;5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2;DAPH 2;DAPH-7;PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem;1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
6 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 2mg
- 2.5mg
- 5mg
- 10MG
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000185
- Product description5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE 95.00%
- Packaging10MG
- Price$757.97
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number539652
- Product descriptionCGP-53353 The PKC
- Packaging2mg
- Price$272
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberC7866
- Product descriptionCGP-53353 solid
- Packaging5mg
- Price$313
- Updated2022-05-15
- Buy
- ManufacturerTocris
- Product number2442
- Product descriptionCGP53353 ≥99%(HPLC)
- Packaging10
- Price$265
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberC583575
- Product descriptionCGP53353
- Packaging2.5mg
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number254940
- Product descriptionCGP 53353
- Packaging10mg
- Price$531
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | INB0000185 | 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE 95.00% | 10MG | $757.97 | 2021-12-16 | Buy |
| Sigma-Aldrich | 539652 | CGP-53353 The PKC | 2mg | $272 | 2024-03-01 | Buy |
| Sigma-Aldrich | C7866 | CGP-53353 solid | 5mg | $313 | 2022-05-15 | Buy |
| Tocris | 2442 | CGP53353 ≥99%(HPLC) | 10 | $265 | 2021-12-16 | Buy |
| TRC | C583575 | CGP53353 | 2.5mg | $325 | 2021-12-16 | Buy |
| Usbiological | 254940 | CGP 53353 | 10mg | $531 | 2021-12-16 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :solid
color :orange
solubility :DMSO: >10mg/mL
form :solid
color :orange
Safety Information
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Description
DAPH-7 is a highly selective procarcinogenic protein kinase C-βII (PKCβII) inhibitor that can also inhibit nPKCs and aPKCs, and upregulate VCAM-1, in a dose dependent manner. The compound has been shown to inhibit a variety of kinases, such as, protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM. Studies show that inhibitory DAPHs can reconstruct Sup35 prion-specific intermolecular interfaces to create morphologically altered aggregates with diminished infectivity and self-templating activity. When DAPHs alter the folding of Sup35s amyloidogenic core it blocks amyloidogenic oligomerization and specific recognition events that nucleate prion assembly. Research shows that DAPH-7, also known as, CGP-53353, can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells.More related product prices
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