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ChemicalBook >> CAS DataBase List >> (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE

(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE

(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE price.
  • $32 - $1138.78
  • Product name: (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE
  • CAS: 169675-09-6
  • MF: C15H16ClFN2O4
  • MW: 342.75
  • EINECS:
  • MDL Number:MFCD06798313
  • Synonyms:RO 60-0175 FUMARATE;1H-Indole-1-ethanaMine, 6-chloro-5-fluoro-a-Methyl-, (aS)-, (2E)-2-butenedioate;(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE;(alpha-S)-6-Chloro-5-fluoro-alpha-methyl-(1H)-indole-1-ethaneaminefumarate;(S)-2-(Chloro-5-fluoro-indol-L-yl)-1-methylethylamine fumarate;1H-Indole-1-ethanamine, 6-chloro-5-fluoro-alpha-methyl-, (alphas)-, (2E)-2-butenedioate (1:1);1H-Indole-1-ethanamine, 6-chloro-5-fluoro-alpha-methyl-, (S)-, (E)-2-butenedioate (1:1);(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate
13 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 1mg
  • 5mg
  • 10MG
  • 10
  • 50MG
  • 100mg
  • ManufacturerAK Scientific
  • Product number3277BB
  • Product descriptionRo60-0175fumarate
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3277BB
  • Product descriptionRo60-0175fumarate
  • Packaging5mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBRS0000200
  • Product description(ALPHA S)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE 95.00%
  • Packaging10MG
  • Price$275.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBRS0000200
  • Product description(ALPHA S)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE 95.00%
  • Packaging50MG
  • Price$1138.78
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6878
  • Product descriptionRo60-0175fumarate
  • Packaging10mg
  • Price$234
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6878
  • Product descriptionRo60-0175fumarate
  • Packaging50mg
  • Price$975
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29520
  • Product descriptionRo 60-0175
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29520
  • Product descriptionRo 60-0175
  • Packaging5mg
  • Price$86
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29520
  • Product descriptionRo 60-0175
  • Packaging10mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number1854
  • Product descriptionRo60-0175fumarate ≥98%(HPLC)
  • Packaging10
  • Price$159
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number1854
  • Product descriptionRo60-0175fumarate ≥98%(HPLC)
  • Packaging50
  • Price$658
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberR639713
  • Product descriptionRo60-0175Fumarate
  • Packaging100mg
  • Price$925
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number256488
  • Product descriptionRo 60-0175 fumarate
  • Packaging10mg
  • Price$409
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3277BB Ro60-0175fumarate 1mg $133 2021-12-16 Buy
AK Scientific 3277BB Ro60-0175fumarate 5mg $218 2021-12-16 Buy
American Custom Chemicals Corporation BRS0000200 (ALPHA S)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE 95.00% 10MG $275.1 2021-12-16 Buy
American Custom Chemicals Corporation BRS0000200 (ALPHA S)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE 95.00% 50MG $1138.78 2021-12-16 Buy
ApexBio Technology B6878 Ro60-0175fumarate 10mg $234 2021-12-16 Buy
ApexBio Technology B6878 Ro60-0175fumarate 50mg $975 2021-12-16 Buy
Cayman Chemical 29520 Ro 60-0175 1mg $32 2024-03-01 Buy
Cayman Chemical 29520 Ro 60-0175 5mg $86 2024-03-01 Buy
Cayman Chemical 29520 Ro 60-0175 10mg $138 2021-12-16 Buy
Tocris 1854 Ro60-0175fumarate ≥98%(HPLC) 10 $159 2021-12-16 Buy
Tocris 1854 Ro60-0175fumarate ≥98%(HPLC) 50 $658 2021-12-16 Buy
TRC R639713 Ro60-0175Fumarate 100mg $925 2021-12-16 Buy
Usbiological 256488 Ro 60-0175 fumarate 10mg $409 2021-12-16 Buy

Properties

storage temp. :Desiccate at RT
solubility :Soluble to 5 mM in water and to 20 mM in DMSO
form :Powder
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Ro 60-0175 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2 that stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT2A, 5-HT2B, and 5-HT2C receptors (EC50s = 447, 0.9, and 32 nM, respectively). It is selective for human 5-HT2A and 5-HT2C (Kis = 32 and 1 nM, respectively) over human 5-HT1A, 5-HT1D, 5-HT6, and 5-HT7, rat 5-HT1B and 5-HT3, and guinea pig 5-HT4 receptors (Kis = ≥1,995 nM), as well as adenosine A1 and A2, histamine H1-3, dopamine D1-5, α1-, α2-, and β1-adrenergic, M1-5 muscarinic, nicotinic, kainate, AMPA, and μ-, δ-, and κ-opioid receptors (IC50s = >1,000 nM), but does bind to β2-adrenergic receptors (IC50 = 251 nM). In vivo, Ro 60-0175 increases plasma levels of corticosterone, oxytocin, and prolactin in rats (ED50s = 2.43, 4.19, and 4.03 mg/kg, respectively), effects that are not inhibited by the 5-HT2C antagonist SB-242084 or the 5-HT2A antagonist MDL 100,907 (volinanserin; ).

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