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ChemicalBook >> CAS DataBase List >> 2'2'-cGAMP

2'2'-cGAMP

2'2'-cGAMP price.
  • $422 - $714
  • Product name: 2'2'-cGAMP
  • CAS: 1465774-27-9
  • MF: C20H24N10O13P2
  • MW: 674.411
  • EINECS:-0
  • MDL Number:
  • Synonyms:2'2'-cGAMP;2’2’-cGAMP (sodium salt);2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt;2'2'-cGAMP (sodium salt)
Price2 Properties Safety Information Description
2 prices
Selected condition：
Brand
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • ManufacturerCayman Chemical
  • Product number22419
  • Product description2’2’-cGAMP (sodium salt)
  • Packaging500μg
  • Price$422
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22419
  • Product description2’2’-cGAMP (sodium salt)
  • Packaging1mg
  • Price$714
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 22419 2’2’-cGAMP (sodium salt) 500μg $422 2024-03-01 Buy
Cayman Chemical 22419 2’2’-cGAMP (sodium salt) 1mg $714 2024-03-01 Buy

Properties

Boiling point :1159.9±75.0 °C(Predicted)
Density :2.61±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Water: soluble
form :A crystalline solid
pka :0.88±0.70(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).

Suppliers and manufacturers

BOC Sciences BOC Sciences Shanghai EFE Biological Technology Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Nanjing Tengyi Biotechnology Co., Ltd TargetMol Chemicals Inc.