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ChemicalBook >> CAS DataBase List >> bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide

bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide price.
  • $25 - $2150
  • Product name: bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
  • CAS: 314045-39-1
  • MF: C24H24N6O2S3
  • MW: 524.68
  • EINECS:
  • MDL Number:MFCD01079848
  • Synonyms:bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide;bis-2-(5-phenylaQtMido-1,2,4-Thiadiazol-2-yl)Ethylsulfide;Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide;BPTES;Glutaminase Inhibitor II, BPTES;N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide;CS-1542;Glutaminase Inhibitor II
32 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Apolloscientific
  • Ark Pharm
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 10
  • 1mg
  • 5mg
  • 10mM(in 1mL DMSO)
  • 10mg
  • 50
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3690-M001
  • Product descriptionBPTES ≥95%(HPLC)
  • Packaging1mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2874CK
  • Product descriptionN,N'-[Sulfanediylbis(Ethane-2,1-Diyl-1,3,4-Thiadiazole-5,2-Diyl)]bis(2-Phenylacetamide)
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2874CK
  • Product descriptionN,N'-[Sulfanediylbis(Ethane-2,1-Diyl-1,3,4-Thiadiazole-5,2-Diyl)]bis(2-Phenylacetamide)
  • Packaging5mg
  • Price$193
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA413914
  • Product descriptionBPTES 98+%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA413914
  • Product descriptionBPTES 98+%
  • Packaging10mg
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA413914
  • Product descriptionBPTES 98+%
  • Packaging25mg
  • Price$148
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA413914
  • Product descriptionBPTES 98+%
  • Packaging50mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA413914
  • Product descriptionBPTES 98+%
  • Packaging100mg
  • Price$494
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA413914
  • Product descriptionBPTES 98+%
  • Packaging250mg
  • Price$741
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA413914
  • Product descriptionBPTES 98+%
  • Packaging1g
  • Price$2150
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6008
  • Product descriptionBPTES
  • Packaging10mM(in 1mL DMSO)
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6008
  • Product descriptionBPTES
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0095
  • Product descriptionBPTES
  • Packaging5mg
  • Price$131
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0095
  • Product descriptionBPTES
  • Packaging10mg
  • Price$196
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0095
  • Product descriptionBPTES
  • Packaging25mg
  • Price$283
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532701
  • Product descriptionBPTES 98+%
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3690-M001 BPTES ≥95%(HPLC) 1mg $25 2021-12-16 Buy
AK Scientific 2874CK N,N'-[Sulfanediylbis(Ethane-2,1-Diyl-1,3,4-Thiadiazole-5,2-Diyl)]bis(2-Phenylacetamide) 1mg $133 2021-12-16 Buy
AK Scientific 2874CK N,N'-[Sulfanediylbis(Ethane-2,1-Diyl-1,3,4-Thiadiazole-5,2-Diyl)]bis(2-Phenylacetamide) 5mg $193 2021-12-16 Buy
Ambeed A413914 BPTES 98+% 5mg $60 2021-12-16 Buy
Ambeed A413914 BPTES 98+% 10mg $78 2021-12-16 Buy
Ambeed A413914 BPTES 98+% 25mg $148 2021-12-16 Buy
Ambeed A413914 BPTES 98+% 50mg $252 2021-12-16 Buy
Ambeed A413914 BPTES 98+% 100mg $494 2021-12-16 Buy
Ambeed A413914 BPTES 98+% 250mg $741 2021-12-16 Buy
Ambeed A413914 BPTES 98+% 1g $2150 2021-12-16 Buy
ApexBio Technology B6008 BPTES 10mM(in 1mL DMSO) $70 2021-12-16 Buy
ApexBio Technology B6008 BPTES 10mg $80 2021-12-16 Buy
Apolloscientific BISN0095 BPTES 5mg $131 2021-12-16 Buy
Apolloscientific BISN0095 BPTES 10mg $196 2021-12-16 Buy
Apolloscientific BISN0095 BPTES 25mg $283 2021-12-16 Buy
Ark Pharm P000532701 BPTES 98+% 5mg $105 2021-12-16 Buy

Properties

Density :1.420±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :9.13±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

BPTES (314045-39-1) is a potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 μM2.? Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6

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