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ChemicalBook >> CAS DataBase List >> N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA

N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA

N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA price.
  • $29 - $3213
  • Product name: N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
  • CAS: 501925-31-1
  • MF: C13H14ClN3O4
  • MW: 311.72
  • EINECS:
  • MDL Number:MFCD00095313
  • Synonyms:PNU 120596;N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA;N-(5-Chloro-2,4-dimethoxphenyl)-N'-(5-methyl-3-isoxazolyl)-urea;1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea;Nsc 216666;Urea, N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-;PNU-120596;PNU120596; NSC 216666;CS-224
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  • ManufacturerAHH
  • Product numberMT-05096
  • Product descriptionN-(5-Chloro-2,4-dimethoxphenyl)-N'-(5-methyl-3-isoxazolyl)urea 98%
  • Packaging0.05g
  • Price$435
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberX7583
  • Product description1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea
  • Packaging10mg
  • Price$164
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116736
  • Product descriptionPNU-120596 99+%
  • Packaging5mg
  • Price$29
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116736
  • Product descriptionPNU-120596 99+%
  • Packaging10mg
  • Price$49
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116736
  • Product descriptionPNU-120596 99+%
  • Packaging50mg
  • Price$145
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116736
  • Product descriptionPNU-120596 99+%
  • Packaging100mg
  • Price$239
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116736
  • Product descriptionPNU-120596 99+%
  • Packaging250mg
  • Price$477
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116736
  • Product descriptionPNU-120596 99+%
  • Packaging1g
  • Price$1188
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1615
  • Product descriptionPNU-120596
  • Packaging10mg
  • Price$50
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  • ManufacturerApexBio Technology
  • Product numberB1615
  • Product descriptionPNU-120596
  • Packaging50mg
  • Price$190
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  • ManufacturerApexBio Technology
  • Product numberB1615
  • Product descriptionPNU-120596
  • Packaging200mg
  • Price$610
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  • ManufacturerBiorbyt Ltd
  • Product numberorb181405
  • Product descriptionPNU-120596 >98%
  • Packaging100mg
  • Price$606.9
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  • ManufacturerBiorbyt Ltd
  • Product numberorb181405
  • Product descriptionPNU-120596 >98%
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  • ManufacturerBiorbyt Ltd
  • Product numberorb181405
  • Product descriptionPNU-120596 >98%
  • Packaging1000mg
  • Price$1949.9
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberBP162686
  • Product descriptionPNU 120596 NEW
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberBP162686
  • Product descriptionPNU 120596 NEW
  • Packaging50mg
  • Price$297.5
  • Updated2021-12-16
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Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-05096 N-(5-Chloro-2,4-dimethoxphenyl)-N'-(5-methyl-3-isoxazolyl)urea 98% 0.05g $435 2021-12-16 Buy
AK Scientific X7583 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea 10mg $164 2021-12-16 Buy
Ambeed A116736 PNU-120596 99+% 5mg $29 2021-12-16 Buy
Ambeed A116736 PNU-120596 99+% 10mg $49 2021-12-16 Buy
Ambeed A116736 PNU-120596 99+% 50mg $145 2021-12-16 Buy
Ambeed A116736 PNU-120596 99+% 100mg $239 2021-12-16 Buy
Ambeed A116736 PNU-120596 99+% 250mg $477 2021-12-16 Buy
Ambeed A116736 PNU-120596 99+% 1g $1188 2021-12-16 Buy
ApexBio Technology B1615 PNU-120596 10mg $50 2021-12-16 Buy
ApexBio Technology B1615 PNU-120596 50mg $190 2021-12-16 Buy
ApexBio Technology B1615 PNU-120596 200mg $610 2021-12-16 Buy
Biorbyt Ltd orb181405 PNU-120596 >98% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb181405 PNU-120596 >98% 250mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb181405 PNU-120596 >98% 1000mg $1949.9 2021-12-16 Buy
Biosynth Carbosynth BP162686 PNU 120596 NEW 10mg $85 2021-12-16 Buy
Biosynth Carbosynth BP162686 PNU 120596 NEW 50mg $297.5 2021-12-16 Buy

Properties

Boiling point :385.0±42.0 °C(Predicted)
Density :1.403
storage temp. :room temp
solubility :DMSO: >10mg/mL
pka :11.72±0.70(Predicted)
form :White solid
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PNU-120596 is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM). It has no detectable effect on α4β2, α3β4, or α9β10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats. It also reduces the cortical/subcortical infarct volume caused by transient focal cerebral ischemia in rats.