N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
- CAS No.
- 501925-31-1
- Chemical Name:
- N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
- Synonyms
- CS-224;PNU 120596;Nsc 216666;PNU 120596 NEW;PNU120596 PNU-120596;PNU-120596 (NSC-216666);PNU-120596;PNU120596; NSC 216666;PNU-120596 - CAS 501925-31-1 - Calbiochem;1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea;N-(5-Chloro-2,4-dimethoxphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
- CBNumber:
- CB8850568
- Molecular Formula:
- C13H14ClN3O4
- Molecular Weight:
- 311.72
- MDL Number:
- MFCD00095313
- MOL File:
- 501925-31-1.mol
- MSDS File:
- SDS
| Boiling point | 385.0±42.0 °C(Predicted) |
|---|---|
| Density | 1.403 |
| storage temp. | room temp |
| solubility | DMSO: >10mg/mL |
| pka | 11.72±0.70(Predicted) |
| form | White solid |
| color | white to off-white |
| FDA UNII | 9EZT3PTH2J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0043 | PNU-120596 ≥98% (HPLC) | 501925-31-1 | 5mg | $132 | 2024-03-01 | Buy |
| Sigma-Aldrich | 528201 | PNU-120596 | 501925-31-1 | 10mg | $225 | 2024-03-01 | Buy |
| Cayman Chemical | 14304 | PNU-120596 ≥98% | 501925-31-1 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 14304 | PNU-120596 ≥98% | 501925-31-1 | 10mg | $87 | 2024-03-01 | Buy |
| Sigma-Aldrich | P0043 | PNU-120596 ≥98% (HPLC) | 501925-31-1 | 25mg | $505 | 2024-03-01 | Buy |
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Chemical Properties,Uses,Production
Uses
PNU 120596 is a type II positive allosteric modulator.
Definition
ChEBI: 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea is a member of ureas.
Biological Activity
Positive allosteric modulator of α 7 neuronal nicotinic acetylcholine receptors (EC 50 = 216 nM), with no detectable effect on α 4 β 2, α 3 β 4 and α 9 α 10 receptors. Active in vivo following systemic administration.
Biochem/physiol Actions
An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.
storage
Desiccate at +4°C
References
[1] hurst r s, hajós m, raggenbass m, et al. a novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. the journal of neuroscience, 2005, 25(17): 4396-4405.
[2] bertrand d, gopalakrishnan m. allosteric modulation of nicotinic acetylcholine receptors. biochemical pharmacology, 2007, 74(8): 1155-1163.
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22787 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 |
View Lastest Price from N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | PNU-120596
501925-31-1
|
US $34.00-113.00 / mg | 98.34% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-02 | N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
501925-31-1
|
US $1.00 / KG | 1KG | 98% | 1lg; 2kg; 5kg; 10kg; 100kg | Career Henan Chemical Co |
-
- PNU-120596
501925-31-1
- US $34.00-113.00 / mg
- 98.34%
- TargetMol Chemicals Inc.
-
- N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
501925-31-1
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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