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ChemicalBook >> CAS DataBase List >> 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one price.
  • $28 - $3018
  • Product name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
  • CAS: 5291-32-7
  • MF: C10H17NO3
  • MW: 199.25
  • EINECS:
  • MDL Number:MFCD20620963
  • Synonyms:2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one;APR-246;PRIMA-1MET;2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one;1-Azabicyclo[2.2.2]octan-3-one, 2-(hydroxymethyl)-2-(methoxymethyl)-;2-(Hydroxymethyl)-2-(methoxymethyl)-3-quinuclidinone;PRIMA-1MET 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one APR-246;APR246;APR 246
Price28 Properties Safety Information Description
28 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 1unit
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 10
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number1247DJ
  • Product descriptionPrima-1met
  • Packaging100mg
  • Price$253
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA631504
  • Product descriptionAPR-246 97%
  • Packaging5mg
  • Price$126
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA631504
  • Product descriptionAPR-246 97%
  • Packaging10mg
  • Price$163
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA631504
  • Product descriptionAPR-246 97%
  • Packaging25mg
  • Price$211
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA631504
  • Product descriptionAPR-246 97%
  • Packaging50mg
  • Price$274
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA631504
  • Product descriptionAPR-246 97%
  • Packaging100mg
  • Price$355
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA631504
  • Product descriptionAPR-246 97%
  • Packaging1g
  • Price$3018
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4484
  • Product descriptionPRIMA-1MET
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4484
  • Product descriptionPRIMA-1MET
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4484
  • Product descriptionPRIMA-1MET
  • Packaging10mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number9000487
  • Product descriptionPRIMA-1MET ≥95%
  • Packaging5mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number9000487
  • Product descriptionPRIMA-1MET ≥95%
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number9000487
  • Product descriptionPRIMA-1MET ≥95%
  • Packaging25mg
  • Price$219
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number9000487
  • Product descriptionPRIMA-1MET
  • Packaging50mg
  • Price$401
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11110174
  • Product descriptionAPR-246 97%
  • Packaging10mg
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11110174
  • Product descriptionAPR-246 97%
  • Packaging25mg
  • Price$119
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1247DJ Prima-1met 100mg $253 2021-12-16 Buy
Ambeed A631504 APR-246 97% 5mg $126 2021-12-16 Buy
Ambeed A631504 APR-246 97% 10mg $163 2021-12-16 Buy
Ambeed A631504 APR-246 97% 25mg $211 2021-12-16 Buy
Ambeed A631504 APR-246 97% 50mg $274 2021-12-16 Buy
Ambeed A631504 APR-246 97% 100mg $355 2021-12-16 Buy
Ambeed A631504 APR-246 97% 1g $3018 2021-12-16 Buy
ApexBio Technology A4484 PRIMA-1MET 1unit $28 2021-12-16 Buy
ApexBio Technology A4484 PRIMA-1MET 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A4484 PRIMA-1MET 10mg $98 2021-12-16 Buy
Cayman Chemical 9000487 PRIMA-1MET ≥95% 5mg $68 2024-03-01 Buy
Cayman Chemical 9000487 PRIMA-1MET ≥95% 10mg $109 2024-03-01 Buy
Cayman Chemical 9000487 PRIMA-1MET ≥95% 25mg $219 2024-03-01 Buy
Cayman Chemical 9000487 PRIMA-1MET 50mg $401 2024-03-01 Buy
Crysdot CD11110174 APR-246 97% 10mg $56 2021-12-16 Buy
Crysdot CD11110174 APR-246 97% 25mg $119 2021-12-16 Buy
Next Last

Properties

Melting point :115-116 °C
Boiling point :313.8±17.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 20 mg/ml)
form :powder
pka :13.99±0.10(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PRIMA-1MET?(5291-32-7) reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1?It induces p53-dependent mitochondrial apoptosis?via?activation of caspase-2.2?PRIMA-1MET?showed significant antitumor activity in multiple myeloma?via?activation of p733?and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET?has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7?PRIMA-1MET?probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8

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APR-246 (PRIMA-1MET)
$10.00 /10KG
APR-246 (PRIMA-1MET) CAS:5291-32-7
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