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ChemicalBook >> CAS DataBase List >> LFM-A13

LFM-A13

LFM-A13 price.
  • $55 - $1462.58
  • Product name: LFM-A13
  • CAS: 244240-24-2
  • MF: C11H8Br2N2O2
  • MW: 360
  • EINECS:
  • MDL Number:MFCD09878279
  • Synonyms:α-cyano-β-hydroxy-β-methyl-n-(2,5-dibromophenyl)propenamide;(Z)-2-cyano-N-(2,5-dibroMophenyl)-3-hydroxybut-2-enaMide(LFM-A13);(Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide;(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide;a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide;2-cyano-N-(2,5-dibromophenyl) -3-oxobutanamide;LFM-A13(Z);2-Butenamide,2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-, (2Z)-
27 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3781AH
  • Product description(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
  • Packaging5mg
  • Price$174
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3781AH
  • Product description(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
  • Packaging10mg
  • Price$241
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3781AH
  • Product description(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
  • Packaging50mg
  • Price$694
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3781AH
  • Product description(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
  • Packaging100mg
  • Price$1139
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000952
  • Product description(2Z)-2-CYANO-N-(2,5-DIBROMOPHENYL)-3-HYDROXY-2-BUTENAMIDE 95.00%
  • Packaging5MG
  • Price$640.33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000952
  • Product description(2Z)-2-CYANO-N-(2,5-DIBROMOPHENYL)-3-HYDROXY-2-BUTENAMIDE 95.00%
  • Packaging50MG
  • Price$1069.65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000952
  • Product description(2Z)-2-CYANO-N-(2,5-DIBROMOPHENYL)-3-HYDROXY-2-BUTENAMIDE 95.00%
  • Packaging100MG
  • Price$1462.58
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5952
  • Product descriptionLFM-A13
  • Packaging5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5952
  • Product descriptionLFM-A13
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5952
  • Product descriptionLFM-A13
  • Packaging50mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5952
  • Product descriptionLFM-A13
  • Packaging200mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2862
  • Product descriptionLFM-A13 99%
  • Packaging10mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010265
  • Product descriptionLFM-A13 ≥98%
  • Packaging5mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010265
  • Product descriptionLFM-A13 ≥98%
  • Packaging10mg
  • Price$130
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010265
  • Product descriptionLFM-A13 ≥98%
  • Packaging50mg
  • Price$535
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010265
  • Product descriptionLFM-A13 ≥98%
  • Packaging100mg
  • Price$936
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3781AH (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide 5mg $174 2021-12-16 Buy
AK Scientific 3781AH (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide 10mg $241 2021-12-16 Buy
AK Scientific 3781AH (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide 50mg $694 2021-12-16 Buy
AK Scientific 3781AH (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide 100mg $1139 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000952 (2Z)-2-CYANO-N-(2,5-DIBROMOPHENYL)-3-HYDROXY-2-BUTENAMIDE 95.00% 5MG $640.33 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000952 (2Z)-2-CYANO-N-(2,5-DIBROMOPHENYL)-3-HYDROXY-2-BUTENAMIDE 95.00% 50MG $1069.65 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000952 (2Z)-2-CYANO-N-(2,5-DIBROMOPHENYL)-3-HYDROXY-2-BUTENAMIDE 95.00% 100MG $1462.58 2021-12-16 Buy
ApexBio Technology B5952 LFM-A13 5mg $55 2021-12-16 Buy
ApexBio Technology B5952 LFM-A13 10mg $70 2021-12-16 Buy
ApexBio Technology B5952 LFM-A13 50mg $280 2021-12-16 Buy
ApexBio Technology B5952 LFM-A13 200mg $700 2021-12-16 Buy
Axon Medchem Axon2862 LFM-A13 99% 10mg $99 2021-12-16 Buy
Cayman Chemical 10010265 LFM-A13 ≥98% 5mg $68 2024-03-01 Buy
Cayman Chemical 10010265 LFM-A13 ≥98% 10mg $130 2024-03-01 Buy
Cayman Chemical 10010265 LFM-A13 ≥98% 50mg $535 2024-03-01 Buy
Cayman Chemical 10010265 LFM-A13 ≥98% 100mg $936 2024-03-01 Buy

Properties

Melting point :150-151 °C
Boiling point :487.9±45.0 °C(Predicted)
Density :1.909±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: 15 mg/mL
form :powder
pka :5.20±0.50(Predicted)
color :white
Stability :Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Description

LFM-A13 (244240-24-2) is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC50‘s = 2.5 μM (recombinant BTK) and 17.2 μM (human BTK).1,2 It has also been shown to inhibit Polo-like kinase (PLK) – IC50 = 61 μM for human PLK3.3 LFM-A13 displayed no activity (concentrations up to 278 μM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten other tyrosine kinases.3

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