RNA Polymerase III Inhibitor
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- $150 - $1350
- Product name: RNA Polymerase III Inhibitor
- CAS: 577784-91-9
- MF: C19H15Cl2N3O2S2
- MW: 452.38
- EINECS:
- MDL Number:MFCD00112663
- Synonyms:RNA Polymerase III Inhibitor;2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide;InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-;transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218;RNA Polymerase III Inhibitor inhibitor;2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide
6 prices
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Brand
- ChemScene
- Sigma-Aldrich
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 ≥99.0%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 ≥99.0%
- Packaging10mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 ≥99.0%
- Packaging25mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 ≥99.0%
- Packaging50mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 ≥99.0%
- Packaging100mg
- Price$1350
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number557403
- Product descriptionRNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively). - Packaging10mg
- Price$403
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 10mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 25mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 50mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 100mg | $1350 | 2021-12-16 | Buy |
| Sigma-Aldrich | 557403 | RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively). |
10mg | $403 | 2024-03-01 | Buy |
Properties
storage temp. := -70C
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
form :Off-white solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
form :Off-white solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety Information
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Description
ML-60218 is a small molecule inhibitor of RNA polymerase III in both S. cerevisiae and human with IC50 values of 32 and 27 μM, respectively. At 200 μM, it has been shown to inhibit 88, 94, and 90% of the in vitro transcription activity of S. cerevisiae, C. albicans, and human RNA polmerase III, respectively. In combination with HDAC inhibition, ML-60218 at 100 μM has been used to target transcription during exocrine pancreatic epithelial proliferation in a zebrafish model of pancreatic cancer.Related product price
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